Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals

Robert G. Caldwell, Joanna B. Wilson, Steven J. Anderson, Richard Longnecker*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

453 Scopus citations

Abstract

Epstein-Barr virus (EBV) establishes a persistent latent infection in peripheral B lymphocytes in humans and is associated with a variety of malignancies and proliferative disorders. Latent membrane protein 2A (LMP2A) is one of only two viral proteins expressed in latently infected B lymphocytes in vivo. LMP2A blocks B cell receptor (BCR) signal transduction in vitro by binding the Syk and Lyn protein tyrosine kinases. To analyze the significance of LMP2A expression in vivo, transgenic mice with B cell lineage expression of LMP2A were generated. LMP2A expression results in the bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin- negative cells to colonize peripheral lymphoid organs, indicating that LMP2A possesses a constitutive signaling activity in nontransformed cells.

Original languageEnglish (US)
Pages (from-to)405-411
Number of pages7
JournalImmunity
Volume9
Issue number3
DOIs
StatePublished - Sep 1998

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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