TY - JOUR
T1 - Epstein-Barr virus LMP2A
T2 - Regulating cellular ubiquitination processes for maintenance of viral latency?
AU - Portis, Toni
AU - Ikeda, Masato
AU - Longnecker, Richard
N1 - Funding Information:
This work was supported in part by Public Health Service grants from the National Cancer Institute and the National Institute of Dental and Craniofacial Research, from the Leukemia and Lymphoma Society of America and a Howard Hughes support grant from the Center for Genetic Medicine at Northwestern University.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2004/8/1
Y1 - 2004/8/1
N2 - Epstein-Barr virus (EBV) is a potentially oncogenic herpesvirus that persists in the B lymphocytes of most individuals. LMP2A might function as a central mediator of viral latency, allowing for long-term survival of infected B cells by providing a surrogate B-cell receptor signal. Recent studies support a model in which LMP2A utilizes ubiquitin-dependent processes to modulate cellular signaling pathways, including the Wnt and Notch pathways. Whether these pathways are exploited by LMP2A to maintain cell survival or to regulate viral gene expression during viral latency remains to be determined. These processes must be further explored to identify the factors that contribute to the maintenance of viral latency and possibly the development of EBV-associated malignancies.
AB - Epstein-Barr virus (EBV) is a potentially oncogenic herpesvirus that persists in the B lymphocytes of most individuals. LMP2A might function as a central mediator of viral latency, allowing for long-term survival of infected B cells by providing a surrogate B-cell receptor signal. Recent studies support a model in which LMP2A utilizes ubiquitin-dependent processes to modulate cellular signaling pathways, including the Wnt and Notch pathways. Whether these pathways are exploited by LMP2A to maintain cell survival or to regulate viral gene expression during viral latency remains to be determined. These processes must be further explored to identify the factors that contribute to the maintenance of viral latency and possibly the development of EBV-associated malignancies.
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U2 - 10.1016/j.it.2004.05.009
DO - 10.1016/j.it.2004.05.009
M3 - Article
C2 - 15275641
AN - SCOPUS:3242715050
SN - 1471-4906
VL - 25
SP - 422
EP - 426
JO - Trends in Immunology
JF - Trends in Immunology
IS - 8
ER -