Erratum: Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1 (Journal of the American Chemical Society (2022) 144: 40 (18688−186990) DOI: 10.1021/jacs.2c08964)

Supporting Information (PDF). We inadvertently included the incorrect 1 H NMR and 13C NMR spectra for compounds YT117R and YT117S. We have updated the Supporting Information with the correct spectra and also included chiral supercritical fluid chromatography traces for these compounds. We also corrected the compound numbers in Figure S6 to read YT47R and YT47S. Supporting Information. The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/jacs.3c05058. Computational model showing the stereoselective engagement of DCAF1_C1113 by MY-1B; computational model of conjugation strategies of the MY-1B core scaffold; abolishing DCAF1 engagement by switching acrylamide to butynamide; concentration-dependent and time-dependent degradation of FKBP12 by DCAF1-directed electrophilic PROTACs; degradation of recombinantly expressed HA-FKBP12, of endogenous FKBP12, and of endogenous BRD4 by DCAF1-directed electrophilic PROTACs; comparing DCAF1 engagement by YT117R and YT47R; binding of DCAF1 near C1113 by a reversible small molecule CYCA-117-70; list of proteins showing substantial and significant changes in abundance in YT47-treated HEK293T cells; biological materials and methods; whole gels and Western blots; and synthetic chemistry (corrected) (PDF).