Erythrocyte membrane phosphorylation in untreated and in etretinate‐treated psoriatic patients

R. KUMAR*, VIRGINIA C.WEISS, D. P. WEST, LAURA A.CHIERO

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Levels of phosphorylation were decreased in bands 2 to 2.1, 2.9 to 3 and 4‐5 to 4‐8 of erythrocyte membranes from psoriatic patients compared with control values. In addition, higher than control levels of 32P were incorporated into a new polypeptide hand (mol. wt. 18‐20,000 daltons) of red cell membranes from patients. Uptake of 32P by these bands returned towards normal after the patients received oral etretmate treatment. These results suggest there is a gcneralixed plasma membrane defect in psoriasis and that ctretinate may affect the metabolism of red cell membrane proteins.

Original languageEnglish (US)
Pages (from-to)277-286
Number of pages10
JournalBritish Journal of Dermatology
Volume109
Issue number3
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Dermatology

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