Abstract
Red blood cells and megakaryocytes arise from a common precursor, the megakaryocyte-erythroid progenitor and share many regulators including the transcription factors GATA-1 and GFI-1B and signaling molecules such as JAK2 and STAT5. These lineages also share the distinction of being associated with rare, but aggressive malignancies that have very poor prognoses. In this review, we will briefly summarize features of normal development of red blood cells and megakaryocytes and also highlight events that lead to their leukemic transformation. It is clear that much more work needs to be done to improve our understanding of the unique biology of these leukemias and to pave the way for novel targeted therapeutics.
Original language | English (US) |
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Pages (from-to) | 6803-6815 |
Number of pages | 13 |
Journal | Oncogene |
Volume | 26 |
Issue number | 47 |
DOIs | |
State | Published - Oct 15 2007 |
Funding
We thank Dr Koen van Besien for helpful discussions and apologize to those whose work could not be discussed due to space limitations. Dr Wickrema is supported by grants from the NCI and the Leukemia and Lymphoma Society. Dr Crispino is a scholar of the Leukemia and Lymphoma Society and acknowledges support from the NCI and NIDDK.
Keywords
- AMKL
- Erythroleukemia
- Fli-1
- Friend virus
- GATA1
- Myeloproliferative diseases
- RUNX1
ASJC Scopus subject areas
- Genetics
- Molecular Biology
- Cancer Research