Erythroid and megakaryocytic transformation

A. Wickrema, J. D. Crispino*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

Red blood cells and megakaryocytes arise from a common precursor, the megakaryocyte-erythroid progenitor and share many regulators including the transcription factors GATA-1 and GFI-1B and signaling molecules such as JAK2 and STAT5. These lineages also share the distinction of being associated with rare, but aggressive malignancies that have very poor prognoses. In this review, we will briefly summarize features of normal development of red blood cells and megakaryocytes and also highlight events that lead to their leukemic transformation. It is clear that much more work needs to be done to improve our understanding of the unique biology of these leukemias and to pave the way for novel targeted therapeutics.

Original languageEnglish (US)
Pages (from-to)6803-6815
Number of pages13
JournalOncogene
Volume26
Issue number47
DOIs
StatePublished - Oct 15 2007

Keywords

  • AMKL
  • Erythroleukemia
  • Fli-1
  • Friend virus
  • GATA1
  • Myeloproliferative diseases
  • RUNX1

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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