ESA1 is a histone acetyltransferase that is essential for growth in yeast

Edwin R. Smith, Arri Eisen, Weigang Gu, Martin Sattah, Antonio Pannuti, Jianxin Zhou, Richard G. Cook, John C. Lucchesi, C. David Allis*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

250 Scopus citations

Abstract

Posttranslational acetylation of core histone amino termini has long been associated with transcriptionally active chromatin. Recent reports have demonstrated histone acetyltransferase activity in a small group of conserved transcriptional regulators directly linked to gene activation. In addition, the presence of a putative acetyltransferase domain has been discovered in a group of proteins known as the MYST family (for its founding members MOZ, YBF2/SAS3, SAS2, and Tip60). Members of this family are implicated in acute myeloid leukemia (MOZ), transcriptional silencing in yeast (SAS2 and YBF2/SAS3), HIV Tat interaction in humans (Tip60), and dosage compensation in Drosophila (MOF). In this report, we express a yeast ORF with homology to MYST family members and show it possesses histone acetyltransferase activity. Unlike the other MYST family members in Saccharomyces cerevisiae this gene is essential for growth.

Original languageEnglish (US)
Pages (from-to)3561-3565
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume95
Issue number7
DOIs
StatePublished - Mar 31 1998

ASJC Scopus subject areas

  • General

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