Escalating Threat Levels of Bacterial Infection Can Be Discriminated by Distinct MAPK and NF-κB Signaling Dynamics in Single Host Cells

Keara Michelle Lane, Marta Andres-Terre, Takamasa Kudo, Denise M. Monack*, Markus W. Covert

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Lane et al. use live-cell imaging to connect macrophage NF-κB and JNK signaling dynamics with distinct bacterial inputs. They identify a role for host signaling dynamics in bacterial threat assessment, and this may enable TLRs, a general bacterial detection system, to generate stimulus-specific responses.

Original languageEnglish (US)
Pages (from-to)183-196.e4
JournalCell Systems
Volume8
Issue number3
DOIs
StatePublished - Mar 27 2019

Keywords

  • MAPKs
  • NF-κB
  • Salmonella
  • TLR signaling
  • dynamics
  • host-pathogen interactions
  • live-cell microscopy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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