ESMO consensus guidelines for the management of patients with metastatic colorectal cancer

Eric Van Cutsem*, A. Cervantes, R. Adam, A. Sobrero, J. H. Van Krieken, D. Aderka, E. Aranda Aguilar, A. Bardelli, A. Benson, G. Bodoky, F. Ciardiello, A. D'Hoore, E. Diaz-Rubio, J. Y. Douillard, M. Ducreux, A. Falcone, A. Grothey, T. Gruenberger, K. Haustermans, V. HeinemannP. Hoff, C. H. Köhne, R. Labianca, P. Laurent-Puig, B. Ma, T. Maughan, K. Muro, N. Normanno, P. österlund, W. J G Oyen, D. Papamichael, G. Pentheroudakis, P. Pfeiffer, T. J. Price, C. Punt, J. Ricke, A. Roth, R. Salazar, W. Scheithauer, H. J. Schmoll, J. Tabernero, J. Taïeb, S. Tejpar, H. Wasan, T. Yoshino, A. Zaanan, D. Arnold

*Corresponding author for this work

Research output: Contribution to journalArticle

710 Citations (Scopus)

Abstract

Colorectal cancer (CRC) is one of the most common malignancies in Western countries. Over the last 20 years, and the last decade in particular, the clinical outcome for patients with metastatic CRC (mCRC) has improved greatly due not only to an increase in the number of patients being referred for and undergoing surgical resection of their localised metastatic disease but also to a more strategic approach to the delivery of systemic therapy and an expansion in the use of ablative techniques. This reflects the increase in the number of patients that are being managed within a multidisciplinary team environment and specialist cancer centres, and the emergence over the same time period not only of improved imaging techniques but also prognostic and predictive molecular markers. Treatment decisions for patients with mCRC must be evidence-based. Thus, these ESMO consensus guidelines have been developed based on the current available evidence to provide a series of evidence-based recommendations to assist in the treatment and management of patients with mCRC in this rapidly evolving treatment setting.

Original languageEnglish (US)
Pages (from-to)1386-1422
Number of pages37
JournalAnnals of Oncology
Volume27
Issue number8
DOIs
StatePublished - Aug 1 2016

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Colorectal Neoplasms
Guidelines
Therapeutics
Neoplasms

Keywords

  • Clinical practice guidelines
  • Colorectal cancer
  • Consensus
  • ESMO

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

Van Cutsem, E., Cervantes, A., Adam, R., Sobrero, A., Van Krieken, J. H., Aderka, D., ... Arnold, D. (2016). ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. Annals of Oncology, 27(8), 1386-1422. https://doi.org/10.1093/annonc/mdw235
Van Cutsem, Eric ; Cervantes, A. ; Adam, R. ; Sobrero, A. ; Van Krieken, J. H. ; Aderka, D. ; Aranda Aguilar, E. ; Bardelli, A. ; Benson, A. ; Bodoky, G. ; Ciardiello, F. ; D'Hoore, A. ; Diaz-Rubio, E. ; Douillard, J. Y. ; Ducreux, M. ; Falcone, A. ; Grothey, A. ; Gruenberger, T. ; Haustermans, K. ; Heinemann, V. ; Hoff, P. ; Köhne, C. H. ; Labianca, R. ; Laurent-Puig, P. ; Ma, B. ; Maughan, T. ; Muro, K. ; Normanno, N. ; österlund, P. ; Oyen, W. J G ; Papamichael, D. ; Pentheroudakis, G. ; Pfeiffer, P. ; Price, T. J. ; Punt, C. ; Ricke, J. ; Roth, A. ; Salazar, R. ; Scheithauer, W. ; Schmoll, H. J. ; Tabernero, J. ; Taïeb, J. ; Tejpar, S. ; Wasan, H. ; Yoshino, T. ; Zaanan, A. ; Arnold, D. / ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. In: Annals of Oncology. 2016 ; Vol. 27, No. 8. pp. 1386-1422.
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title = "ESMO consensus guidelines for the management of patients with metastatic colorectal cancer",
abstract = "Colorectal cancer (CRC) is one of the most common malignancies in Western countries. Over the last 20 years, and the last decade in particular, the clinical outcome for patients with metastatic CRC (mCRC) has improved greatly due not only to an increase in the number of patients being referred for and undergoing surgical resection of their localised metastatic disease but also to a more strategic approach to the delivery of systemic therapy and an expansion in the use of ablative techniques. This reflects the increase in the number of patients that are being managed within a multidisciplinary team environment and specialist cancer centres, and the emergence over the same time period not only of improved imaging techniques but also prognostic and predictive molecular markers. Treatment decisions for patients with mCRC must be evidence-based. Thus, these ESMO consensus guidelines have been developed based on the current available evidence to provide a series of evidence-based recommendations to assist in the treatment and management of patients with mCRC in this rapidly evolving treatment setting.",
keywords = "Clinical practice guidelines, Colorectal cancer, Consensus, ESMO",
author = "{Van Cutsem}, Eric and A. Cervantes and R. Adam and A. Sobrero and {Van Krieken}, {J. H.} and D. Aderka and {Aranda Aguilar}, E. and A. Bardelli and A. Benson and G. Bodoky and F. Ciardiello and A. D'Hoore and E. Diaz-Rubio and Douillard, {J. Y.} and M. Ducreux and A. Falcone and A. Grothey and T. Gruenberger and K. Haustermans and V. Heinemann and P. Hoff and K{\"o}hne, {C. H.} and R. Labianca and P. Laurent-Puig and B. Ma and T. Maughan and K. Muro and N. Normanno and P. {\"o}sterlund and Oyen, {W. J G} and D. Papamichael and G. Pentheroudakis and P. Pfeiffer and Price, {T. J.} and C. Punt and J. Ricke and A. Roth and R. Salazar and W. Scheithauer and Schmoll, {H. J.} and J. Tabernero and J. Ta{\"i}eb and S. Tejpar and H. Wasan and T. Yoshino and A. Zaanan and D. Arnold",
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Van Cutsem, E, Cervantes, A, Adam, R, Sobrero, A, Van Krieken, JH, Aderka, D, Aranda Aguilar, E, Bardelli, A, Benson, A, Bodoky, G, Ciardiello, F, D'Hoore, A, Diaz-Rubio, E, Douillard, JY, Ducreux, M, Falcone, A, Grothey, A, Gruenberger, T, Haustermans, K, Heinemann, V, Hoff, P, Köhne, CH, Labianca, R, Laurent-Puig, P, Ma, B, Maughan, T, Muro, K, Normanno, N, österlund, P, Oyen, WJG, Papamichael, D, Pentheroudakis, G, Pfeiffer, P, Price, TJ, Punt, C, Ricke, J, Roth, A, Salazar, R, Scheithauer, W, Schmoll, HJ, Tabernero, J, Taïeb, J, Tejpar, S, Wasan, H, Yoshino, T, Zaanan, A & Arnold, D 2016, 'ESMO consensus guidelines for the management of patients with metastatic colorectal cancer', Annals of Oncology, vol. 27, no. 8, pp. 1386-1422. https://doi.org/10.1093/annonc/mdw235

ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. / Van Cutsem, Eric; Cervantes, A.; Adam, R.; Sobrero, A.; Van Krieken, J. H.; Aderka, D.; Aranda Aguilar, E.; Bardelli, A.; Benson, A.; Bodoky, G.; Ciardiello, F.; D'Hoore, A.; Diaz-Rubio, E.; Douillard, J. Y.; Ducreux, M.; Falcone, A.; Grothey, A.; Gruenberger, T.; Haustermans, K.; Heinemann, V.; Hoff, P.; Köhne, C. H.; Labianca, R.; Laurent-Puig, P.; Ma, B.; Maughan, T.; Muro, K.; Normanno, N.; österlund, P.; Oyen, W. J G; Papamichael, D.; Pentheroudakis, G.; Pfeiffer, P.; Price, T. J.; Punt, C.; Ricke, J.; Roth, A.; Salazar, R.; Scheithauer, W.; Schmoll, H. J.; Tabernero, J.; Taïeb, J.; Tejpar, S.; Wasan, H.; Yoshino, T.; Zaanan, A.; Arnold, D.

In: Annals of Oncology, Vol. 27, No. 8, 01.08.2016, p. 1386-1422.

Research output: Contribution to journalArticle

TY - JOUR

T1 - ESMO consensus guidelines for the management of patients with metastatic colorectal cancer

AU - Van Cutsem, Eric

AU - Cervantes, A.

AU - Adam, R.

AU - Sobrero, A.

AU - Van Krieken, J. H.

AU - Aderka, D.

AU - Aranda Aguilar, E.

AU - Bardelli, A.

AU - Benson, A.

AU - Bodoky, G.

AU - Ciardiello, F.

AU - D'Hoore, A.

AU - Diaz-Rubio, E.

AU - Douillard, J. Y.

AU - Ducreux, M.

AU - Falcone, A.

AU - Grothey, A.

AU - Gruenberger, T.

AU - Haustermans, K.

AU - Heinemann, V.

AU - Hoff, P.

AU - Köhne, C. H.

AU - Labianca, R.

AU - Laurent-Puig, P.

AU - Ma, B.

AU - Maughan, T.

AU - Muro, K.

AU - Normanno, N.

AU - österlund, P.

AU - Oyen, W. J G

AU - Papamichael, D.

AU - Pentheroudakis, G.

AU - Pfeiffer, P.

AU - Price, T. J.

AU - Punt, C.

AU - Ricke, J.

AU - Roth, A.

AU - Salazar, R.

AU - Scheithauer, W.

AU - Schmoll, H. J.

AU - Tabernero, J.

AU - Taïeb, J.

AU - Tejpar, S.

AU - Wasan, H.

AU - Yoshino, T.

AU - Zaanan, A.

AU - Arnold, D.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Colorectal cancer (CRC) is one of the most common malignancies in Western countries. Over the last 20 years, and the last decade in particular, the clinical outcome for patients with metastatic CRC (mCRC) has improved greatly due not only to an increase in the number of patients being referred for and undergoing surgical resection of their localised metastatic disease but also to a more strategic approach to the delivery of systemic therapy and an expansion in the use of ablative techniques. This reflects the increase in the number of patients that are being managed within a multidisciplinary team environment and specialist cancer centres, and the emergence over the same time period not only of improved imaging techniques but also prognostic and predictive molecular markers. Treatment decisions for patients with mCRC must be evidence-based. Thus, these ESMO consensus guidelines have been developed based on the current available evidence to provide a series of evidence-based recommendations to assist in the treatment and management of patients with mCRC in this rapidly evolving treatment setting.

AB - Colorectal cancer (CRC) is one of the most common malignancies in Western countries. Over the last 20 years, and the last decade in particular, the clinical outcome for patients with metastatic CRC (mCRC) has improved greatly due not only to an increase in the number of patients being referred for and undergoing surgical resection of their localised metastatic disease but also to a more strategic approach to the delivery of systemic therapy and an expansion in the use of ablative techniques. This reflects the increase in the number of patients that are being managed within a multidisciplinary team environment and specialist cancer centres, and the emergence over the same time period not only of improved imaging techniques but also prognostic and predictive molecular markers. Treatment decisions for patients with mCRC must be evidence-based. Thus, these ESMO consensus guidelines have been developed based on the current available evidence to provide a series of evidence-based recommendations to assist in the treatment and management of patients with mCRC in this rapidly evolving treatment setting.

KW - Clinical practice guidelines

KW - Colorectal cancer

KW - Consensus

KW - ESMO

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DO - 10.1093/annonc/mdw235

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Van Cutsem E, Cervantes A, Adam R, Sobrero A, Van Krieken JH, Aderka D et al. ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. Annals of Oncology. 2016 Aug 1;27(8):1386-1422. https://doi.org/10.1093/annonc/mdw235