Esophageal and esophagogastric junction cancers, Version 1.2015

Jaffer A. Ajani, Thomas A. D'Amico, Khaldoun Almhanna, David J. Bentrem, Stephen Besh, Joseph Chao, Prajnan Das, Crystal Denlinger, Paul Fanta, Charles S. Fuchs, Hans Gerdes, Robert E. Glasgow, James A. Hayman, Steven Hochwald, Wayne L. Hofstetter, David H. Ilson, Dawn Jaroszewski, Kory Jasperson, Rajesh N. Keswani, Lawrence R. KleinbergW. Michael Korn, Stephen Leong, A. Craig Lockhart, Mary F. Mulcahy, Mark B. Orringer, James A. Posey, George A. Poultsides, Aaron R. Sasson, Walter J. Scott, Vivian E. Strong, Thomas K. Varghese, Mary Kay Washington, Christopher G. Willett, Cameron D. Wright, Debra Zelman, Nicole McMillian, Hema Sundar

Research output: Contribution to journalReview article

219 Scopus citations

Abstract

Esophageal cancer is the sixth most common cause of cancer deaths worldwide. Adenocarcinoma is more common in North America and Western European countries, originating mostly in the lower third of the esophagus, which often involves the esophagogastric junction (EGJ). Recent randomized trials have shown that the addition of preoperative chemoradiation or perioperative chemotherapy to surgery significantly improves survival in patients with resectable cancer. Targeted therapies with trastuzumab and ramucirumab have produced encouraging results in the treatment of advanced or metastatic EGJ adenocarcinomas. Multidisciplinary team management is essential for patients with esophageal and EGJ cancers. This portion of the NCCN Guidelines for Esophageal and EGJ Cancers discusses management of locally advanced adenocarcinoma of the esophagus and EGJ.

Original languageEnglish (US)
Pages (from-to)194-227
Number of pages34
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume13
Issue number2
DOIs
StatePublished - Feb 1 2015

ASJC Scopus subject areas

  • Oncology

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    Ajani, J. A., D'Amico, T. A., Almhanna, K., Bentrem, D. J., Besh, S., Chao, J., Das, P., Denlinger, C., Fanta, P., Fuchs, C. S., Gerdes, H., Glasgow, R. E., Hayman, J. A., Hochwald, S., Hofstetter, W. L., Ilson, D. H., Jaroszewski, D., Jasperson, K., Keswani, R. N., ... Sundar, H. (2015). Esophageal and esophagogastric junction cancers, Version 1.2015. JNCCN Journal of the National Comprehensive Cancer Network, 13(2), 194-227. https://doi.org/10.6004/jnccn.2015.0028