Esophageal motility abnormalities in Barrett's esophagus

Kumar Krishnan*, John E. Pandolfino, Peter J. Kahrilas

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A prerequisite for the development of Barrett's esophagus (BE) is gastro-esophageal reflux disease (GERD). Previous studies have noted that patients with Barrett's esophagus have a substantial amount of reflux, comparable to patients with erosive esophagitis. The pathologic effect of GERD on the esophagus is determined by both the frequency of reflux events and the duration of esophageal mucosal contact time with each reflux event. There is a paucity of data on whether patients with BE have unique motor abnormalities that predispose them to a heavy reflux burden. Here, we discuss the mechanisms of reflux and the common anatomic and physiologic abnormalities in the context of patients with BE.

Original languageEnglish (US)
Title of host publicationEsophageal Cancer and Barrett's Esophagus
PublisherWiley Blackwell
Pages45-54
Number of pages10
ISBN (Electronic)9781118655153
ISBN (Print)9781118655207
DOIs
StatePublished - Dec 12 2015

Keywords

  • Acid reflux
  • Barrett's esophagus
  • Bile reflux
  • Esophageal manometry
  • Esophageal motility
  • GERD
  • Hiatal hernia
  • Intestinal metaplasia
  • Lower esophageal sphincter
  • Peristalsis

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Krishnan, K., Pandolfino, J. E., & Kahrilas, P. J. (2015). Esophageal motility abnormalities in Barrett's esophagus. In Esophageal Cancer and Barrett's Esophagus (pp. 45-54). Wiley Blackwell. https://doi.org/10.1002/9781118655153.ch5