Establishing equivalence between scaled measures of quality of life

R. Gonin*, S. Lloyd, D. Cella

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


In this paper, methodologies which have been used in the pharmaceutical industry to demonstrate the equivalence of drug preparations, are applied to the measurement of quality of life (QOL). This approach is feasible when the generated data are measured on the same scale. Data from the quality of life instruments are transformed into interval scales by means of an appropriate scaling procedure. It is demonstrated that equivalence of QOL instruments is linked by a linear relationship between the QOL instruments Functional Assessment of Cancer Therapy (FACT) and the Functional Living Index-Cancer (FLIC). The linear relationship is derived using orthogonal least squares regression which takes into account that both measures are subject to error.

Original languageEnglish (US)
Pages (from-to)20-26
Number of pages7
JournalQuality of Life Research
Issue number1
StatePublished - 1996


  • Bias
  • Bio-equivalence
  • Bootstrap standard errors
  • Functional Assessment of Cancer Therapy
  • Functional Living Index-Cancer
  • Orthogonal least squares
  • Quality of life

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


Dive into the research topics of 'Establishing equivalence between scaled measures of quality of life'. Together they form a unique fingerprint.

Cite this