Esterase-activated release of naproxen from supramolecular nanofibres

Martin Conda-Sheridan, Sungsoo S. Lee, Adam T. Preslar, Samuel I. Stupp*

*Corresponding author for this work

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Nanofibre forming peptide amphiphiles were conjugated to naproxen through an esterase-sensitive linker. The amount of naproxen released, in the presence of enzymes, was influenced by the linker conjugating the drug to the supramolecular assembly. In vitro studies showed the anti-inflammatory activity of the released drug was maintained.

Original languageEnglish (US)
Pages (from-to)13757-13760
Number of pages4
JournalChemical Communications
Volume50
Issue number89
DOIs
StatePublished - Oct 14 2014

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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