Esterase- and pH-responsive poly(β-amino ester)-capped mesoporous silica nanoparticles for drug delivery

Isurika R. Fernando, Daniel P. Ferris, Marco Frasconi, Dmitry Malin, Elena Strekalova, M. Deniz Yilmaz, Michael W. Ambrogio, Mohammed M. Algaradah, Michael P. Hong, Xinqi Chen, Majed S. Nassar, Youssry Y. Botros, Vincent L. Cryns*, J. Fraser Stoddart

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Gating of mesoporous silica nanoparticles (MSNs) with the stimuli-responsive poly(β-amino ester) has been achieved. This hybrid nanocarrier releases doxorubicin (DOX) under acidic conditions or in the presence of porcine liver esterase. The DOX loaded poly(β-amino ester)-capped MSNs reduce cell viability when tested on MDA-MB-231 human breast cancer cells.

Original languageEnglish (US)
Pages (from-to)7178-7183
Number of pages6
JournalNanoscale
Volume7
Issue number16
DOIs
StatePublished - Apr 28 2015

ASJC Scopus subject areas

  • Materials Science(all)

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