Estimates of body fat in children by hologic QDR-2000 and QDR-4500A dual-energy X-ray absorptiometers compared with deuterium dilution

Delphine R. Robotham, Dale A. Schoeller, Arlene B. Mercado, Margaret C. Mirch, Kelly R. Theim, James C. Reynolds, Jack A. Yanovski*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

We evaluated the accuracy with which the Hologic QDR-4500A and QDR-2000 densitometers measure fat mass (FM) in 95 children. FM was derived from total body water measured by deuterium dilution (DD) in all children, by QDR-4500A in 50, and by QDR-2000 in 45 children. Compared with DD, both instruments underestimated FM (QDR-4500A: 3.35 ± 2.5 kg, P < 0.0001; QDR-2000: 1.05 ± 1.5 kg, P < 0.0001). Both absorptiometers showed magnitude biases relative to DD (QDR-4500: r = +0.70, P < 0.001; QDR-2000: r = -0.51, P < 0.001). We conclude that neither densitometer is equivalent to DD for estimation of children's FM. The QDR-4500A's current calibration seems to provide an even greater underestimate of FM than the QDR-2000.

Original languageEnglish (US)
Pages (from-to)331-335
Number of pages5
JournalJournal of pediatric gastroenterology and nutrition
Volume42
Issue number3
DOIs
StatePublished - Mar 2006

Keywords

  • Body composition
  • Calibration
  • Children
  • Dual-energy X-ray absorptiometry
  • Fat mass

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

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