Estimation of cardiac reserve by peak power: Validation and initial application of a simplified index

G. P. Armstrong, S. G. Carlier, K. Fukamachi, J. D. Thomas, T. H. Marwick*

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Objectives - To validate a simplified estimate of peak power (SPP) against true (invasively measured) peak instantaneous power (TPP), to assess the feasibility of measuring SPP during exercise and to correlate this with functional capacity. Design - Development of a simplified method of measurement and observational study. Setting - Tertiary referral centre for cardiothoracic disease. Subjects - For validation of SPP with TPP, seven normal dogs and four dogs with dilated cardiomyopathy were studied. To assess feasibility and clinical significance in humans, 40 subjects were studied (26 patients; 14 normal controls). Methods - In the animal validation study, TPP was derived from ascending aortic pressure and flow probe, and from Doppler measurements of flow. SPP, calculated using the different flow measures, was compared with peak instantaneous power under different loading conditions. For the assessment in humans, SPP was measured at rest and during maximum exercise. Peak aortic flow was measured with transthoracic continuous wave Doppler, and systolic and diastolic blood pressures were derived from brachial sphygmomanometry. The difference between exercise and rest simplified peak power (Δ SPP) was compared with maximum oxygen uptake (VO2max), measured from expired gas analysis. Results - SPP estimates using peak flow measures correlated well with true peak instantaneous power (r = 0.89 to 0.97), despite marked changes in systemic pressure and flow induced by manipulation of loading conditions. In the human study, VO2max correlated with Δ SPP (r = 0.78) better than Δ ejection fraction (r = 0.18) and Δ rate-pressure product (r = 0.59). Conclusions - The simple product of mean arterial pressure and peak aortic flow (simplified peak power, SPP) correlates with peak instantaneous power over a range of loading conditions in dogs. In humans, it can be estimated during exercise echocardiography, and correlates with maximum oxygen uptake better than ejection fraction or rate-pressure product.

Original languageEnglish (US)
Pages (from-to)357-364
Number of pages8
JournalHeart
Volume82
Issue number3
DOIs
StatePublished - 1999

Keywords

  • Cardiac power output
  • Left ventricular function
  • Oxygen consumption
  • Stress echocardiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Estimation of cardiac reserve by peak power: Validation and initial application of a simplified index'. Together they form a unique fingerprint.

Cite this