Estimation of regional pulmonary perfusion parameters from microfocal angiograms

Anne V. Clough, Amir Al-Tinawi, John H. Linehan, Christopher A. Dawson

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


An important application of functional imaging is the estimation of regional blood flow and volume using residue detection of vascular indicators. An indicator-dilution model applicable to tissue regions distal from the inlet site was developed. Theoretical methods for determining regional blood flow, volume and mean transit time parameters from time-absorbance curves arise from this model. The robustness of the parameter estimation methods was evaluated using a computer-simulated vessel network model. Flow through arterioles, networks of capillaries and venules was simulated. Parameter identification and practical implementation issues were addressed. The shape of the inlet concentration curve and moderate amounts of random noise did not effect the ability of the method to recover accurate parameter estimates. The parameter estimates degraded in the presence of significant dispersion of the measured inlet concentration curve as it traveled through arteries upstream from the microvascular region. The methods were applied to image data obtained using microfocal x-ray angiography to study the pulmonary microcirculation. Time-absorbance curves were acquired from a small feeding artery, the surrounding microvasculature and a draining vein of an isolated dog lung as contrast material passed through the field-of-view. Changes in regional microvascular volume were determined from these curves. Keywords: functional imaging; angiography; regional flow; regional vascular volume; mean transit time; residue detection; microcirculation; pulmonary circulation; indicator-dilution.

Original languageEnglish (US)
Pages (from-to)2-14
Number of pages13
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - May 24 1995
Externally publishedYes
EventMedical Imaging 1995: Physiology and Function from Multidimensional Images - San Diego, United States
Duration: Feb 26 1995Mar 2 1995

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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