Estradiol and progesterone potentiate adenosine's depressant action on rat cerebral cortical neurons

J. W. Phillis*, A. S. Bender, W. Marszalec

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

1. 1. The effects of 17β-estradiol and progesterone on the uptake of adenosine by rat cerebral cortical synaptosomes have been correlated with the ability of these gonadal steroids to potentiate the depressant actions of adenosine on the spontaneous firing of rat cerebral cortical neurons. 2. 2. 17β-estradiol hemisuccinate competitively inhibited adenosine uptake with a Ki of 0.5 μM (Lineweaver-Burk plot) or 0.78 μM (Dixon plot). The Ki for progesterone was 0.34 μM (Lineweaver-Burk plot) or 0.36 μM (Dixon plot). 3. 3. When applied by iontophoresis, both steroids potentiated the depressant effects of adenosine on the firing of rat cerebral cortical neurons. 4. 4. Potentiation of the effect of endogenously released adenosine would account for the central depressant actions of these steroids.

Original languageEnglish (US)
Pages (from-to)609-612
Number of pages4
JournalGeneral Pharmacology
Volume16
Issue number6
DOIs
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Pharmacology

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