Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat

C. S. Woolley*, B. S. McEwen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1024 Scopus citations

Abstract

We have found that the density of synapses in the stratum radiatum of the hippocampal CA1 region in the adult female rat is sensitive to estradiol manipulation and fluctuates naturally as the levels of ovarian steroids vary during the 5 d estrous cycle. In both cases, low levels of estradiol are correlated with lower synapse density, while high estradiol levels are correlated with a higher density of synapses. These synaptic changes occur very rapidly in that within approximately 24 hr between the proestrus and estrus stages of the estrous cycle, we observe a 32% decrease in the density of hippocampal synapses. Synapse density then appears to cycle back to proestrus values over a period of several days. To our knowledge, this is the first demonstration of such short-term steroid-mediated synaptic plasticity occurring naturally in the adult mammalian brain.

Original languageEnglish (US)
Pages (from-to)2549-2554
Number of pages6
JournalJournal of Neuroscience
Volume12
Issue number7
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat'. Together they form a unique fingerprint.

Cite this