Estrogen-enhanced neurite growth: Evidence for a selective induction of tau and stable microtubules

A. Ferreira*, A. Caceres

*Corresponding author for this work

Research output: Contribution to journalArticle

173 Scopus citations

Abstract

Estrogen stimulates the neurite outgrowth response of medial basal hypothalamic neurons maintained in culture. We show here that one effect of estrogen is to promote an increase in τ, but not in tubulin, microtubule-associated protein 1a (MAP-1a), or MAP-2 protein levels. This response precedes and accompanies an increase in stable microtubules and in neurite length. Taken collectively, our data suggest that estrogen-enhanced neurite growth is mediated by a selective induction of microtubule-stabilizing factors, namely, the τ proteins.

Original languageEnglish (US)
Pages (from-to)392-400
Number of pages9
JournalJournal of Neuroscience
Volume11
Issue number2
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Neuroscience(all)

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