Estrogen-induced changes in the microtubular system correlate with a decreased susceptibility of aging neurons to beta amyloid neurotoxicity

Ruchir D. Shah, Kelsi L. Anderson, Mark Rapoport, Adriana Ferreira*

*Corresponding author for this work

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

A growing body of evidence suggests that estrogen has beneficial effects on Alzheimer's disease. However, the mechanisms underlying estrogen's neuroprotective effects are not completely understood. In the present study, we analyzed first whether estrogen protects mature hippocampal neurons against fibrillar Aβ-induced neurotoxicity. 17α-Estradiol and 17β-estradiol partially prevented neuronal death induced by fibrillar Aβ. Estrogen-induced neuroprotection correlated with the formation of a more dynamic microtubular system, including an increase in the pool of unstable microtubules and the expression of juvenile microtubule-associated proteins MAP2c and MAP1b. These results provide further evidence that experimental conditions capable of increasing the pool of unstable microtubules might render mature hippocampal neurons resistant to the degeneration caused by fibrillar Aβ deposits.

Original languageEnglish (US)
Pages (from-to)503-516
Number of pages14
JournalMolecular and Cellular Neuroscience
Volume24
Issue number2
DOIs
StatePublished - Oct 2003

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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