Estrogen Receptor Expression of Benign Breast Epithelium and Its Association with Breast Cancer

Seema A. Khan, Mary A M Rogers, Juan A. Obando, Ali Tamsen

Research output: Contribution to journalArticlepeer-review

111 Scopus citations

Abstract

We conducted a case-control study of estrogen receptor (ER) and progesterone receptor (PgR) expression in benign breast epithelium from 120 women (51 breast cancer cases and 69 benign disease controls) who underwent breast operations at University Hospital, Syracuse, New York. Benign samples were obtained and processed immunohistochemically for ER and PgR (Abbott, Chicago, IL). Receptor positivity was defined as any nuclear immunostaining. Proportionately more cases than controls were ER positive (84% versus 57%); PgR positivity was similar in cases and controls (86%). Logistic regression yielded an adjusted odds ratio of 6.5 for breast cancer among ER-positive women (95% confidence interval of 1.5 and 27.4); odds ratio of PgR positivity was 0.3 (95% confidence interval of 0.1 and 1.9). Adjustment for known risk factors for breast cancer did not change the odds ratio. ER-positive breast epithelium needs evaluation as a possible risk marker for breast cancer.

Original languageEnglish (US)
Pages (from-to)993-997
Number of pages5
JournalCancer Research
Volume54
Issue number4
StatePublished - Feb 1994

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Estrogen Receptor Expression of Benign Breast Epithelium and Its Association with Breast Cancer'. Together they form a unique fingerprint.

Cite this