Ethanol impairs the induction of delayed hypersensitivity in C57BL/6 mice

Carl Waltenbaugh*, Jeffrey D. Peterson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Excessive alcohol consumption impairs T-cell-dependent immune function. Whether this impairment results from the direct inhibition of helper T (Th) cells or from inhibition of the cells that process and present antigen to Th cells is unclear. The present study examines the temporal effect of dietary alcohol on the development of delayed hypersensitivity (DTH) in C57BL/6 mice. We find that ethanol consumption just prior to and during the cognitive phase of the immune response impairs the development of a DTH response. Ethanol consumption initiated after the cognitive phase and during the effector phase of the immune response has no significant effect upon the elicitation of a DTH response. The results suggest that significant ethanol-induced impairment of DTH responses occurs during the cognitive phase of the immune response, when antigen presentation and recognition occur.

Original languageEnglish (US)
Pages (from-to)149-153
Number of pages5
JournalAlcohol
Volume14
Issue number2
DOIs
StatePublished - Mar 4 1997

Keywords

  • Alcohol consumption
  • Delayed hypersensitivity
  • Mouse
  • Temporal effects

ASJC Scopus subject areas

  • Health(social science)
  • Biochemistry
  • Toxicology
  • Neurology
  • Behavioral Neuroscience

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