Ethnic-specific differences in bronchodilator responsiveness among African Americans, Puerto Ricans, and Mexicans with asthma

Mariam Naqvi; Shannon Thyne; Shweta Choudhry; Hui Ju Tsai; Daniel Navarro; Richard A. Castro; Sylvette Nazario; Jose R. Rodriguez-Santana; Jesus Casal; Alfonso Torres; Rocio Chapela; H. Geoffrey Watson; Kelley Meade; Michael LeNoir; Pedro C. Avila; William Rodriguez-Cintron; Esteban González Burchard

doi:10.1080/02770900701554441

Ethnic-specific differences in bronchodilator responsiveness among African Americans, Puerto Ricans, and Mexicans with asthma

Mariam Naqvi, Shannon Thyne^*, Shweta Choudhry, Hui Ju Tsai, Daniel Navarro, Richard A. Castro, Sylvette Nazario, Jose R. Rodriguez-Santana, Jesus Casal, Alfonso Torres, Rocio Chapela, H. Geoffrey Watson, Kelley Meade, Michael LeNoir, Pedro C. Avila, William Rodriguez-Cintron, Esteban González Burchard

^*Corresponding author for this work

Medicine, Allergy Division

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

Socioeconomic and environmental differences do not fully explain differences in asthma prevalence, morbidity, and mortality among Puerto Ricans, African Americans, and Mexican Americans. Differences in response to albuterol may be a factor. We compared bronchodilator responsiveness between these three populations. All groups demonstrated below expected responsiveness. Puerto Ricans of all ages and African American children with moderate-to-severe asthma demonstrated the lowest responsiveness overall. Among subjects with moderate-to-severe asthma, children were even less likely than adults to show the expected bronchodilator response. We conclude that ethnic-specific differences in bronchodilator drug responsiveness exist between Mexicans, Puerto Ricans, and African Americans with asthma. This may be of importance in asthma management.

Original language	English (US)
Pages (from-to)	639-648
Number of pages	10
Journal	Journal of Asthma
Volume	44
Issue number	8
DOIs	https://doi.org/10.1080/02770900701554441
State	Published - Oct 2007

Funding

Supported in part by National Institutes of Health (K23 HL04464, HL 078885, HL07185, GM61390, American Lung Association of California, RWJ Amos Medical Faculty Development Award, NCMHD Health Disparities Scholar, Extramural Clinical Research Loan Repayment Program for Individuals from Disadvantaged Backgrounds, 2001–2003, to EGB), American Thoracic Society Breakthrough Opportunities for Lung Disease (BOLD) grant (ATS-05-078) and Tobacco-Related Disease Research Program New Investigator Award (15KT-0008) to SC; Ernest S. Bazley Grant to Northwestern University to PCA; (HL51823, HL074204, 3M01RR000083-38S30488, HL56443 and HL51831 to the Asthma Clinical Research Network), SFGH General Clinical Research Center M01RR00083-41, U01-HL 65899, UCSF-Children’s Hospital of Oakland Pediatric Clinical Research Center (M01 RR01271), Oakland, CA, Sandler Center for Basic Research in Asthma and the Sandler Family Supporting Foundation.

Keywords

African Americans
Asthma
Bronchodilator drug response
Hispanics
Latinos

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Immunology and Allergy
Pulmonary and Respiratory Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/02770900701554441

Cite this

Naqvi, M., Thyne, S., Choudhry, S., Tsai, H. J., Navarro, D., Castro, R. A., Nazario, S., Rodriguez-Santana, J. R., Casal, J., Torres, A., Chapela, R., Watson, H. G., Meade, K., LeNoir, M., Avila, P. C., Rodriguez-Cintron, W., & Burchard, E. G. (2007). Ethnic-specific differences in bronchodilator responsiveness among African Americans, Puerto Ricans, and Mexicans with asthma. Journal of Asthma, 44(8), 639-648. https://doi.org/10.1080/02770900701554441

@article{6a2580a767224bf0a0763cca14f3bb7c,

title = "Ethnic-specific differences in bronchodilator responsiveness among African Americans, Puerto Ricans, and Mexicans with asthma",

abstract = "Socioeconomic and environmental differences do not fully explain differences in asthma prevalence, morbidity, and mortality among Puerto Ricans, African Americans, and Mexican Americans. Differences in response to albuterol may be a factor. We compared bronchodilator responsiveness between these three populations. All groups demonstrated below expected responsiveness. Puerto Ricans of all ages and African American children with moderate-to-severe asthma demonstrated the lowest responsiveness overall. Among subjects with moderate-to-severe asthma, children were even less likely than adults to show the expected bronchodilator response. We conclude that ethnic-specific differences in bronchodilator drug responsiveness exist between Mexicans, Puerto Ricans, and African Americans with asthma. This may be of importance in asthma management.",

keywords = "African Americans, Asthma, Bronchodilator drug response, Hispanics, Latinos",

author = "Mariam Naqvi and Shannon Thyne and Shweta Choudhry and Tsai, {Hui Ju} and Daniel Navarro and Castro, {Richard A.} and Sylvette Nazario and Rodriguez-Santana, {Jose R.} and Jesus Casal and Alfonso Torres and Rocio Chapela and Watson, {H. Geoffrey} and Kelley Meade and Michael LeNoir and Avila, {Pedro C.} and William Rodriguez-Cintron and Burchard, {Esteban Gonz{\'a}lez}",

note = "Funding Information: Supported in part by National Institutes of Health (K23 HL04464, HL 078885, HL07185, GM61390, American Lung Association of California, RWJ Amos Medical Faculty Development Award, NCMHD Health Disparities Scholar, Extramural Clinical Research Loan Repayment Program for Individuals from Disadvantaged Backgrounds, 2001–2003, to EGB), American Thoracic Society Breakthrough Opportunities for Lung Disease (BOLD) grant (ATS-05-078) and Tobacco-Related Disease Research Program New Investigator Award (15KT-0008) to SC; Ernest S. Bazley Grant to Northwestern University to PCA; (HL51823, HL074204, 3M01RR000083-38S30488, HL56443 and HL51831 to the Asthma Clinical Research Network), SFGH General Clinical Research Center M01RR00083-41, U01-HL 65899, UCSF-Children{\textquoteright}s Hospital of Oakland Pediatric Clinical Research Center (M01 RR01271), Oakland, CA, Sandler Center for Basic Research in Asthma and the Sandler Family Supporting Foundation.",

year = "2007",

month = oct,

doi = "10.1080/02770900701554441",

language = "English (US)",

volume = "44",

pages = "639--648",

journal = "Journal of Asthma",

issn = "0277-0903",

publisher = "Taylor & Francis Group LLC Philadelphia",

number = "8",

}

Naqvi, M, Thyne, S, Choudhry, S, Tsai, HJ, Navarro, D, Castro, RA, Nazario, S, Rodriguez-Santana, JR, Casal, J, Torres, A, Chapela, R, Watson, HG, Meade, K, LeNoir, M, Avila, PC, Rodriguez-Cintron, W & Burchard, EG 2007, 'Ethnic-specific differences in bronchodilator responsiveness among African Americans, Puerto Ricans, and Mexicans with asthma', Journal of Asthma, vol. 44, no. 8, pp. 639-648. https://doi.org/10.1080/02770900701554441

TY - JOUR

T1 - Ethnic-specific differences in bronchodilator responsiveness among African Americans, Puerto Ricans, and Mexicans with asthma

AU - Naqvi, Mariam

AU - Thyne, Shannon

AU - Choudhry, Shweta

AU - Tsai, Hui Ju

AU - Navarro, Daniel

AU - Castro, Richard A.

AU - Nazario, Sylvette

AU - Rodriguez-Santana, Jose R.

AU - Casal, Jesus

AU - Torres, Alfonso

AU - Chapela, Rocio

AU - Watson, H. Geoffrey

AU - Meade, Kelley

AU - LeNoir, Michael

AU - Avila, Pedro C.

AU - Rodriguez-Cintron, William

AU - Burchard, Esteban González

N1 - Funding Information: Supported in part by National Institutes of Health (K23 HL04464, HL 078885, HL07185, GM61390, American Lung Association of California, RWJ Amos Medical Faculty Development Award, NCMHD Health Disparities Scholar, Extramural Clinical Research Loan Repayment Program for Individuals from Disadvantaged Backgrounds, 2001–2003, to EGB), American Thoracic Society Breakthrough Opportunities for Lung Disease (BOLD) grant (ATS-05-078) and Tobacco-Related Disease Research Program New Investigator Award (15KT-0008) to SC; Ernest S. Bazley Grant to Northwestern University to PCA; (HL51823, HL074204, 3M01RR000083-38S30488, HL56443 and HL51831 to the Asthma Clinical Research Network), SFGH General Clinical Research Center M01RR00083-41, U01-HL 65899, UCSF-Children’s Hospital of Oakland Pediatric Clinical Research Center (M01 RR01271), Oakland, CA, Sandler Center for Basic Research in Asthma and the Sandler Family Supporting Foundation.

PY - 2007/10

Y1 - 2007/10

N2 - Socioeconomic and environmental differences do not fully explain differences in asthma prevalence, morbidity, and mortality among Puerto Ricans, African Americans, and Mexican Americans. Differences in response to albuterol may be a factor. We compared bronchodilator responsiveness between these three populations. All groups demonstrated below expected responsiveness. Puerto Ricans of all ages and African American children with moderate-to-severe asthma demonstrated the lowest responsiveness overall. Among subjects with moderate-to-severe asthma, children were even less likely than adults to show the expected bronchodilator response. We conclude that ethnic-specific differences in bronchodilator drug responsiveness exist between Mexicans, Puerto Ricans, and African Americans with asthma. This may be of importance in asthma management.

AB - Socioeconomic and environmental differences do not fully explain differences in asthma prevalence, morbidity, and mortality among Puerto Ricans, African Americans, and Mexican Americans. Differences in response to albuterol may be a factor. We compared bronchodilator responsiveness between these three populations. All groups demonstrated below expected responsiveness. Puerto Ricans of all ages and African American children with moderate-to-severe asthma demonstrated the lowest responsiveness overall. Among subjects with moderate-to-severe asthma, children were even less likely than adults to show the expected bronchodilator response. We conclude that ethnic-specific differences in bronchodilator drug responsiveness exist between Mexicans, Puerto Ricans, and African Americans with asthma. This may be of importance in asthma management.

KW - African Americans

KW - Asthma

KW - Bronchodilator drug response

KW - Hispanics

KW - Latinos

UR - http://www.scopus.com/inward/record.url?scp=35448932302&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35448932302&partnerID=8YFLogxK

U2 - 10.1080/02770900701554441

DO - 10.1080/02770900701554441

M3 - Article

C2 - 17943575

AN - SCOPUS:35448932302

SN - 0277-0903

VL - 44

SP - 639

EP - 648

JO - Journal of Asthma

JF - Journal of Asthma

IS - 8

ER -

Ethnic-specific differences in bronchodilator responsiveness among African Americans, Puerto Ricans, and Mexicans with asthma

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this