Ethnicity and risk factors for change in the ankle-brachial index: The Multi-Ethnic Study of Atherosclerosis

Matthew A. Allison*, Mary Cushman, Cam Solomon, Victor Aboyans, Mary M. McDermott, David C. Goff, Michael H. Criqui

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Background: The aim of this study was to determine the risk factors for conversion from a normal to either a low or high ankle-brachial index (ABI). Methods: Participants in the Multi-Ethnic Study of Atherosclerosis who had two separate measurements of the ABI over a 3-year time period were assessed. Results: At baseline, the mean age was 62 years and 50% were women, 28% African American, 12% Chinese, 22% Hispanic and 38% non-Hispanic White. Of the 5514 participants with a baseline ABI between 0.90 and 1.40, 89 (1.6%) had an ABI ≤ 0.90 ("low ABI group") and 71 (1.3%) had an ABI ≥ 1.40 ("high ABI group") 3 years later. On multivariable analysis, the odds for having progressed into the low ABI group were significantly increased for higher baseline age, hypertension, diabetes, greater pack-years of cigarette smoking, and homocysteine levels. The odds for progression into the high ABI group were increased for male gender and higher body mass index. Compared with non-Hispanic Whites, African Americans had a significantly higher odds for progression to the low ABI group (odds ratio [OR]: 2.24, 95% confidence interval [CI]: 1.29-3.88) while having a reduced odds for progression to the high ABI group (OR: 0.50, 95% CI: 0.24-1.00). Neither Chinese nor Hispanic ethnicity was significantly associated with progression to either ABI group. Conclusions: The risk factors for progression to a low or high ABI were distinct and African Americans were at increased risk for progression to a low ABI but at decreased risk for progression into the high ABI group.

Original languageEnglish (US)
Pages (from-to)1049-1056
Number of pages8
JournalJournal of Vascular Surgery
Issue number5
StatePublished - Nov 2009

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery


Dive into the research topics of 'Ethnicity and risk factors for change in the ankle-brachial index: The Multi-Ethnic Study of Atherosclerosis'. Together they form a unique fingerprint.

Cite this