Etiology and Medical Management of Pediatric Intestinal Failure

Ethan A. Mezoff*, Conrad R. Cole, Valeria C. Cohran

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Pediatric intestinal failure occurs when gut function is insufficient to meet the growing child's hydration and nutrition needs. After massive bowel resection, the remnant bowel adapts to lost absorptive and digestive capacity through incompletely defined mechanisms newly targeted for pharmacologic augmentation. Management seeks to achieve enteral autonomy and mitigate the development of comorbid disease. Care has improved, most notably related to reductions in blood stream infection and liver disease. The future likely holds expansion of pharmacologic adaptation augmentation, refinement of intestinal tissue engineering techniques, and the development of a learning health network for efficient multicenter study and care improvement.

Original languageEnglish (US)
Pages (from-to)483-498
Number of pages16
JournalGastroenterology Clinics of North America
Issue number4
StatePublished - Dec 2019


  • Parenteral nutrition
  • Pediatric intestinal failure
  • Short bowel syndrome

ASJC Scopus subject areas

  • Gastroenterology


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