ETS1 Function in Leukemia and Lymphoma

Rebecca A. Luchtel*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

ETS proto-oncogene 1 (ETS1) is a transcription factor (TF) critically involved in lymphoid cell development and function. ETS1 expression is tightly regulated throughout differentiation and activation in T-cells, natural killer (NK) cells, and B-cells. It has also been described as an oncogene in a range of solid and hematologic cancer types. Among hematologic malignancies, its role has been best studied in T-cell acute lymphoblastic leukemia (T-ALL), adult T-cell leukemia/lymphoma (ATLL), and diffuse large B-cell lymphoma (DLBCL). Aberrant expression of ETS1 in these malignancies is driven primarily by chromosomal amplification and enhancer-driven transcriptional regulation, promoting the ETS1 transcriptional program. ETS1 also facilitates aberrantly expressed or activated transcriptional complexes to drive oncogenic pathways. Collectively, ETS1 functions to regulate cell growth, differentiation, signaling, response to stimuli, and viral interactions in these malignancies. A tumor suppressor role has also been indicated for ETS1 in select lymphoma types, emphasizing the importance of cellular context in ETS1 function. Research is ongoing to further characterize the clinical implications of ETS1 dysregulation in hematologic malignancies, to further resolve binding complexes and transcriptional targets, and to identify effective therapeutic targeting approaches.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages359-378
Number of pages20
DOIs
StatePublished - 2024

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1459
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Funding

RL is supported by an American Society of Hematology (ASH) Research Scholar Award.

Keywords

  • B-cell
  • ETS family
  • ETS1
  • Hematologic malignancies
  • Leukemia
  • Lymphoma
  • T-cell
  • Transcription factor

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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