Eukaryotic transcription initiation machinery visualized at molecular level

Yan Han, Yuan He*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


The structures of RNA Polymerase (Pol) II pre-initiation complexes (PIC) have recently been determined at near-atomic resolution, elucidating unprecedented mechanistic details of promoter opening during transcription initiation. The key structural features of promoter opening are summarized here. Structural knowledge of Pol I and III PIC is also briefly discussed.

Original languageEnglish (US)
Pages (from-to)203-208
Number of pages6
Issue number5
StatePublished - Oct 19 2016


  • RNA polymerase
  • general transcription factor
  • pre-initiation complex
  • promoter opening
  • transcription initiation

ASJC Scopus subject areas

  • Genetics
  • Biochemistry
  • Biotechnology


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