European perspective for effective cancer drug development

Denis Lacombe*, Sabine Tejpar, Roberto Salgado, Fatima Cardoso, Vassilis Golfinopoulos, Daniela Aust, Gunnar Folprecht, Arnaud Roth, Roger Stupp

*Corresponding author for this work

Research output: Contribution to journalReview article

34 Scopus citations

Abstract

Health systems and the clinical research landscape evolve continuously owing to increased risk aversion, scrutiny by funding bodies, and costs of clinical trials. In this context, however, current drug development procedures are far from optimal, as exemplified by the late-stage failure of several drugs. The identification of new drugs urgently requires approaches based on a solid understanding of cancer biology, and that will support the design of robust confirmatory trials. The complexity and the costs of drug development are now beyond the knowledge and operational capacity of single organisations, therefore, a drastic deviation from the traditional path of drug discovery and new forms of multidisciplinary partnerships are needed to succeed in this sector. The European Organisation for Research and Treatment of Cancer (EORTC) proposes the use of collaborative molecular screening platforms (CMSPs) as a new approach to tackle this issue. These CMSPs have the advantage of optimizing the expertise of several partners and combining efforts alongside with cost-sharing models for efficient patient selection. This article describes some of the challenges to advancing drug development and improving medical treatments and how these hurdles can be overcome.

Original languageEnglish (US)
Pages (from-to)492-498
Number of pages7
JournalNature Reviews Clinical Oncology
Volume11
Issue number8
DOIs
StatePublished - Jan 1 2014

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ASJC Scopus subject areas

  • Oncology

Cite this

Lacombe, D., Tejpar, S., Salgado, R., Cardoso, F., Golfinopoulos, V., Aust, D., Folprecht, G., Roth, A., & Stupp, R. (2014). European perspective for effective cancer drug development. Nature Reviews Clinical Oncology, 11(8), 492-498. https://doi.org/10.1038/nrclinonc.2014.98