Evaluating Medication Response in ADHD: Cognitive, Behavioral, and Single-Subject Methodology

James B. Hale; Jo Ann B Hoeppner; Mary Beth DeWitt; Daniel L. Coury; David G. Ritacco; Barbara Trommer

doi:10.1177/002221949803100610

Evaluating Medication Response in ADHD: Cognitive, Behavioral, and Single-Subject Methodology

James B. Hale^*, Jo Ann B Hoeppner, Mary Beth DeWitt, Daniel L. Coury, David G. Ritacco, Barbara Trommer

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Although evidence supports the use of double-blind placebo medication trials to evaluate methylphenidate (MPH) effects on the core behavioral symptoms of attention-deficit/hyperactivity disorder (ADHD), few studies have demonstrated their utility in examining MPH effects on the cognitive deficits associated with ADHD. This article presents a technique for evaluating behavioral and cognitive dose-response relationships at the single-subject level of analysis. Case study results and multivariate analyses suggest that systematic evaluation of behavioral and cognitive MPH dose-response relationships could lead to more accurate MPH titration and greater long-term multimodal treatment efficacy.

Original language	English (US)
Pages (from-to)	595-607
Number of pages	13
Journal	Journal of Learning Disabilities
Volume	31
Issue number	6
DOIs	https://doi.org/10.1177/002221949803100610
State	Published - 1998

ASJC Scopus subject areas

Health(social science)
Education
Health Professions(all)

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abstract = "Although evidence supports the use of double-blind placebo medication trials to evaluate methylphenidate (MPH) effects on the core behavioral symptoms of attention-deficit/hyperactivity disorder (ADHD), few studies have demonstrated their utility in examining MPH effects on the cognitive deficits associated with ADHD. This article presents a technique for evaluating behavioral and cognitive dose-response relationships at the single-subject level of analysis. Case study results and multivariate analyses suggest that systematic evaluation of behavioral and cognitive MPH dose-response relationships could lead to more accurate MPH titration and greater long-term multimodal treatment efficacy.",

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AU - Coury, Daniel L.

AU - Ritacco, David G.

AU - Trommer, Barbara

PY - 1998

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AB - Although evidence supports the use of double-blind placebo medication trials to evaluate methylphenidate (MPH) effects on the core behavioral symptoms of attention-deficit/hyperactivity disorder (ADHD), few studies have demonstrated their utility in examining MPH effects on the cognitive deficits associated with ADHD. This article presents a technique for evaluating behavioral and cognitive dose-response relationships at the single-subject level of analysis. Case study results and multivariate analyses suggest that systematic evaluation of behavioral and cognitive MPH dose-response relationships could lead to more accurate MPH titration and greater long-term multimodal treatment efficacy.

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Evaluating Medication Response in ADHD: Cognitive, Behavioral, and Single-Subject Methodology

Abstract

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