Evaluating Medication Response in ADHD: Cognitive, Behavioral, and Single-Subject Methodology

James B. Hale*, Jo Ann B Hoeppner, Mary Beth DeWitt, Daniel L. Coury, David G. Ritacco, Barbara Trommer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Although evidence supports the use of double-blind placebo medication trials to evaluate methylphenidate (MPH) effects on the core behavioral symptoms of attention-deficit/hyperactivity disorder (ADHD), few studies have demonstrated their utility in examining MPH effects on the cognitive deficits associated with ADHD. This article presents a technique for evaluating behavioral and cognitive dose-response relationships at the single-subject level of analysis. Case study results and multivariate analyses suggest that systematic evaluation of behavioral and cognitive MPH dose-response relationships could lead to more accurate MPH titration and greater long-term multimodal treatment efficacy.

Original languageEnglish (US)
Pages (from-to)595-607
Number of pages13
JournalJournal of Learning Disabilities
Issue number6
StatePublished - 1998

ASJC Scopus subject areas

  • Health(social science)
  • Education
  • Health Professions(all)


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