Evaluating the association of allergies with multiple sclerosis susceptibility risk and disease activity in a pediatric population

Theresa Bourne*, Michael Waltz, T. C. Casper, K. Kavak, G. Aaen, A. Belman, L. Benson, M. Candee, T. Chitnis, J. Graves, B. Greenberg, M. Gorman, Y. Harris, L. Krupp, T. Lotze, S. Mar, J. Ness, C. Olsen, S. Roalstad, M. RodriguezJ. Rose, J. Rubin, T. Schreiner, J. M. Tillema, I. Kahn, A. Waldman, L. Barcellos, E. Waubant, B. Weinstock-Guttman, US Network of Pediatric MS Centers

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background Multiple sclerosis (MS) and allergies are both considered to be related to imbalanced Th1 and Th2 immune responses. Previous studies evaluating the relationship between MS and allergies provide conflicting results. Objective To assess allergies and asthma as risk factors for MS and as predictors of MS relapses in a pediatric cohort. Methods The environment and genetic risk factors for pediatric MS study is a national case-control project with 16 participating US sites. An environmental questionnaire is used that includes history of allergies in the first five years of life. Case-control data are entered in the pediatric MS Network database and cases at 12 of the 16 sites enter relapse data prospectively. Annualized relapse rate was calculated for patients with follow-up and adjusted for age at disease onset, gender, race, ethnicity, and use of disease-modifying therapy (DMT). Results We included 271 cases (mean age at disease onset of 15.7 years and 62% female) and 418 controls. Relapse data were available for 193 cases. There was no difference in prevalence of allergies or asthma between cases and controls. Patients with food allergies had fewer relapses compared to patients without food allergies (0.14 vs 0.48, p = 0.01). Conclusions While allergies and asthma are not associated with pediatric MS, cases with food allergies have fewer relapses compared to those without food allergies.

Original languageEnglish (US)
Pages (from-to)371-375
Number of pages5
JournalJournal of the Neurological Sciences
StatePublished - Apr 15 2017


  • Allergies
  • Multiple sclerosis
  • Pediatric

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


Dive into the research topics of 'Evaluating the association of allergies with multiple sclerosis susceptibility risk and disease activity in a pediatric population'. Together they form a unique fingerprint.

Cite this