TY - JOUR
T1 - Evaluating the Potential Association Between Lipoprotein(a) and Atherosclerosis (from the Mediators of Atherosclerosis Among South Asians Living in America Cohort)
AU - Huffman, Mark D.
AU - Kandula, Namratha R.
AU - Baldridge, Abigail S.
AU - Tsai, Michael Y.
AU - Prabhakaran, Dorairaj
AU - Kanaya, Alka M.
N1 - Funding Information:
Funding: The MASALA study was supported by the NIH grant no. 1R01 HL093009. Data collection at UCSF was also supported by NIH/NCRR UCSF-CTSI grant number UL1 RR024131. Lp(a) measurements were supported by the Cliff Lede Family Charitable Foundation. The sponsors did not play a significant role in the analysis, interpretation, and presentation of these results.MDH receives funding from the World Heart Federation for its Emerging Leaders program, which is sponsored by unrestricted educational grants from Boehringer Ingelheim with previous support from Novartis, BUPA, and AstraZeneca. MDH also receives support from One Brave Idea, a research enterprise sponsored by the American Heart Association, Verily, and AstraZeneca. MDH serves as associate editor of JAMA Cardiology for which he receives compensation from the American Medical Association.
Funding Information:
MDH receives funding from the World Heart Federation for its Emerging Leaders program, which is sponsored by unrestricted educational grants from Boehringer Ingelheim with previous support from Novartis , BUPA, and AstraZeneca . MDH also receives support from One Brave Idea, a research enterprise sponsored by the American Heart Association , Verily, and AstraZeneca . MDH serves as associate editor of JAMA Cardiology for which he receives compensation from the American Medical Association .
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2019/3/15
Y1 - 2019/3/15
N2 - We sought to report the distribution of Lp(a) levels in the Mediators of Atherosclerosis among South Asians Living in America cohort of participants who were free from clinical atherosclerotic cardiovascular disease (ASCVD) at baseline and to evaluate the cross-sectional association with atherosclerosis measured by coronary artery calcification (CAC) and carotid intima media thickness. Among 886 participants (mean [SD] age: 55.4 [9.4] years, 54% male), median lipoprotein (a) level was 17 (9, 33) mg/dl. Compared with the lowest quartile (9 mg/dl), subjects in the highest Lp(a) quartile (33 to 178 mg/dl) were more likely to be women (51% vs 37%, p <0.01) and had a higher mean (SD) total cholesterol (193 [37] mg/dl vs 181 [35] mg/dl, p <0.01). CAC was present in 42% and both the presence and degree of CAC was similar across Lp(a) quartiles (p = 0.58). Median Interquartile range (IQR) common and internal carotid intima-media thickness (IMT) thicknesses were 0.84 (0.73, 0.98) mm and 1.12 (0.95, 1.34) mm, respectively, and were also similar across Lp(a) quartiles. After adjustment for cardiovascular risk factors, Lp(a) quartile had no association with prevalent CAC (p = 0.98), internal carotid IMT (p = 0.46), or common carotid IMT (p = 0.97). Among South Asian Americans, mean Lp(a) levels were higher than previous reports among Whites, Hispanic/Latino, and Chinese-Americans but lower than in Blacks. Unlike findings from other race/ethnic groups, Lp(a) levels were not associated with atherosclerosis among South Asian Americans.
AB - We sought to report the distribution of Lp(a) levels in the Mediators of Atherosclerosis among South Asians Living in America cohort of participants who were free from clinical atherosclerotic cardiovascular disease (ASCVD) at baseline and to evaluate the cross-sectional association with atherosclerosis measured by coronary artery calcification (CAC) and carotid intima media thickness. Among 886 participants (mean [SD] age: 55.4 [9.4] years, 54% male), median lipoprotein (a) level was 17 (9, 33) mg/dl. Compared with the lowest quartile (9 mg/dl), subjects in the highest Lp(a) quartile (33 to 178 mg/dl) were more likely to be women (51% vs 37%, p <0.01) and had a higher mean (SD) total cholesterol (193 [37] mg/dl vs 181 [35] mg/dl, p <0.01). CAC was present in 42% and both the presence and degree of CAC was similar across Lp(a) quartiles (p = 0.58). Median Interquartile range (IQR) common and internal carotid intima-media thickness (IMT) thicknesses were 0.84 (0.73, 0.98) mm and 1.12 (0.95, 1.34) mm, respectively, and were also similar across Lp(a) quartiles. After adjustment for cardiovascular risk factors, Lp(a) quartile had no association with prevalent CAC (p = 0.98), internal carotid IMT (p = 0.46), or common carotid IMT (p = 0.97). Among South Asian Americans, mean Lp(a) levels were higher than previous reports among Whites, Hispanic/Latino, and Chinese-Americans but lower than in Blacks. Unlike findings from other race/ethnic groups, Lp(a) levels were not associated with atherosclerosis among South Asian Americans.
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U2 - 10.1016/j.amjcard.2018.12.013
DO - 10.1016/j.amjcard.2018.12.013
M3 - Article
C2 - 30626499
AN - SCOPUS:85059485812
SN - 0002-9149
VL - 123
SP - 919
EP - 921
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 6
ER -
