Evaluation and management of hyponatremia: An emerging role for vasopressin receptor antagonists

Sheldon Chen, Nishant Jalandhara, Daniel Batlle*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Vasopressin-2 receptor antagonists, collectively known as the 'vaptans', provide a new approach to the treatment of hyponatremia; therefore, an updated Review of the pathophysiology of hyponatremia is particularly timely. After briefly defining hyponatremia and introducing its clinical aspects and complications, we present an approach to the diagnosis and evaluation of hyponatremia that is based primarily on the often-underused concept of free water clearance and, more specifically, the electrolyte-free water clearance. Then we review the use of vasopressin receptor antagonists in the management of hyponatremia from the standpoint of their pharmacology, their mechanism of action, and available efficacy data from clinical trials.

Original languageEnglish (US)
Pages (from-to)82-95
Number of pages14
JournalNature Clinical Practice Nephrology
Volume3
Issue number2
DOIs
StatePublished - Feb 2007

Keywords

  • Aquaretics
  • Electrolyte-free water clearance
  • Hyponatremia
  • Vasopressin antagonists

ASJC Scopus subject areas

  • Nephrology

Fingerprint Dive into the research topics of 'Evaluation and management of hyponatremia: An emerging role for vasopressin receptor antagonists'. Together they form a unique fingerprint.

Cite this