Evaluation and Management of Primary Hyperaldosteronism

Frances T. Lee, Dina M Elaraj*

*Corresponding author for this work

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Primary hyperaldosteronism is an important and increasingly prevalent cause of hypertension that is characterized by unregulated aldosterone excess. More than 90% of primary hyperaldosteronism cases are attributable to either idiopathic adrenal hyperplasia or aldosterone-producing adenomas. The approach to the diagnosis of primary hyperaldosteronism should be step-wise, starting with screening of at-risk populations, confirmatory testing for positively screened patients, and subtype classification in order to direct surgical or medical management. Based on current guidelines, subtype classification of primary hyperaldosteronism should be determined with both imaging and adrenal vein sampling (AVS), reserving deferment of AVS for a selective subset of patients.

Original languageEnglish (US)
Pages (from-to)731-745
Number of pages15
JournalSurgical Clinics of North America
Volume99
Issue number4
DOIs
StatePublished - Aug 1 2019

Fingerprint

Hyperaldosteronism
Aldosterone
Veins
Adenoma
Hyperplasia
Guidelines
Hypertension

Keywords

  • Adenoma
  • Adrenal hyperplasia
  • Aldosterone excess
  • Hyperaldosteronism
  • Primary hyperaldosteronism

ASJC Scopus subject areas

  • Surgery

Cite this

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title = "Evaluation and Management of Primary Hyperaldosteronism",
abstract = "Primary hyperaldosteronism is an important and increasingly prevalent cause of hypertension that is characterized by unregulated aldosterone excess. More than 90{\%} of primary hyperaldosteronism cases are attributable to either idiopathic adrenal hyperplasia or aldosterone-producing adenomas. The approach to the diagnosis of primary hyperaldosteronism should be step-wise, starting with screening of at-risk populations, confirmatory testing for positively screened patients, and subtype classification in order to direct surgical or medical management. Based on current guidelines, subtype classification of primary hyperaldosteronism should be determined with both imaging and adrenal vein sampling (AVS), reserving deferment of AVS for a selective subset of patients.",
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}

Evaluation and Management of Primary Hyperaldosteronism. / Lee, Frances T.; Elaraj, Dina M.

In: Surgical Clinics of North America, Vol. 99, No. 4, 01.08.2019, p. 731-745.

Research output: Contribution to journalReview article

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T1 - Evaluation and Management of Primary Hyperaldosteronism

AU - Lee, Frances T.

AU - Elaraj, Dina M

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N2 - Primary hyperaldosteronism is an important and increasingly prevalent cause of hypertension that is characterized by unregulated aldosterone excess. More than 90% of primary hyperaldosteronism cases are attributable to either idiopathic adrenal hyperplasia or aldosterone-producing adenomas. The approach to the diagnosis of primary hyperaldosteronism should be step-wise, starting with screening of at-risk populations, confirmatory testing for positively screened patients, and subtype classification in order to direct surgical or medical management. Based on current guidelines, subtype classification of primary hyperaldosteronism should be determined with both imaging and adrenal vein sampling (AVS), reserving deferment of AVS for a selective subset of patients.

AB - Primary hyperaldosteronism is an important and increasingly prevalent cause of hypertension that is characterized by unregulated aldosterone excess. More than 90% of primary hyperaldosteronism cases are attributable to either idiopathic adrenal hyperplasia or aldosterone-producing adenomas. The approach to the diagnosis of primary hyperaldosteronism should be step-wise, starting with screening of at-risk populations, confirmatory testing for positively screened patients, and subtype classification in order to direct surgical or medical management. Based on current guidelines, subtype classification of primary hyperaldosteronism should be determined with both imaging and adrenal vein sampling (AVS), reserving deferment of AVS for a selective subset of patients.

KW - Adenoma

KW - Adrenal hyperplasia

KW - Aldosterone excess

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