Evaluation and treatment approaches for neurological post-acute sequelae of COVID-19: A consensus statement and scoping review from the global COVID-19 neuro research coalition

Jennifer A. Frontera*, Alla Guekht, Ricardo F. Allegri, Mariam Ashraf, Betül Baykan, Lucía Crivelli, Ava Easton, David Garcia-Azorin, Raimund Helbok, Jatin Joshi, Julia Koehn, Igor Koralnik, M. Netravathi, Benedict Michael, Annacarmen Nilo, Aynur Özge, Karanbir Padda, Gaia Pellitteri, Kameshwar Prasad, Marina RomozziDeanna Saylor, Adam Seed, Kiran Thakur, Derya Uluduz, Alberto Vogrig, Tamara M. Welte, Erica Westenberg, Dmitry Zhuravlev, Mikhail Zinchuk, Andrea S. Winkler

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Post-acute neurological sequelae of COVID-19 affect millions of people worldwide, yet little data is available to guide treatment strategies for the most common symptoms. We conducted a scoping review of PubMed/Medline from 1/1/2020–4/1/2023 to identify studies addressing diagnosis and treatment of the most common post-acute neurological sequelae of COVID-19 including: cognitive impairment, sleep disorders, headache, dizziness/lightheadedness, fatigue, weakness, numbness/pain, anxiety, depression and post-traumatic stress disorder. Utilizing the available literature and international disease-specific society guidelines, we constructed symptom-based differential diagnoses, evaluation and management paradigms. This pragmatic, evidence-based consensus document may serve as a guide for a holistic approach to post-COVID neurological care and will complement future clinical trials by outlining best practices in the evaluation and treatment of post-acute neurological signs/symptoms.

Original languageEnglish (US)
Article number120827
JournalJournal of the Neurological Sciences
Volume454
DOIs
StatePublished - Nov 15 2023

Keywords

  • COVID-19
  • Diagnosis
  • Evaluation
  • Management
  • Neurologic
  • SARS-COV-2
  • Therapeutics
  • Therapy
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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