Evaluation and treatment approaches for neurological post-acute sequelae of COVID-19: A consensus statement and scoping review from the global COVID-19 neuro research coalition

Jennifer A. Frontera; Alla Guekht; Ricardo F. Allegri; Mariam Ashraf; Betül Baykan; Lucía Crivelli; Ava Easton; David Garcia-Azorin; Raimund Helbok; Jatin Joshi; Julia Koehn; Igor Koralnik; M. Netravathi; Benedict Michael; Annacarmen Nilo; Aynur Özge; Karanbir Padda; Gaia Pellitteri; Kameshwar Prasad; Marina Romozzi; Deanna Saylor; Adam Seed; Kiran Thakur; Derya Uluduz; Alberto Vogrig; Tamara M. Welte; Erica Westenberg; Dmitry Zhuravlev; Mikhail Zinchuk; Andrea S. Winkler

doi:10.1016/j.jns.2023.120827

Evaluation and treatment approaches for neurological post-acute sequelae of COVID-19: A consensus statement and scoping review from the global COVID-19 neuro research coalition

Jennifer A. Frontera^*, Alla Guekht, Ricardo F. Allegri, Mariam Ashraf, Betül Baykan, Lucía Crivelli, Ava Easton, David Garcia-Azorin, Raimund Helbok, Jatin Joshi, Julia Koehn, Igor Koralnik, M. Netravathi, Benedict Michael, Annacarmen Nilo, Aynur Özge, Karanbir Padda, Gaia Pellitteri, Kameshwar Prasad, Marina RomozziDeanna Saylor, Adam Seed, Kiran Thakur, Derya Uluduz, Alberto Vogrig, Tamara M. Welte, Erica Westenberg, Dmitry Zhuravlev, Mikhail Zinchuk, Andrea S. Winkler

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Post-acute neurological sequelae of COVID-19 affect millions of people worldwide, yet little data is available to guide treatment strategies for the most common symptoms. We conducted a scoping review of PubMed/Medline from 1/1/2020–4/1/2023 to identify studies addressing diagnosis and treatment of the most common post-acute neurological sequelae of COVID-19 including: cognitive impairment, sleep disorders, headache, dizziness/lightheadedness, fatigue, weakness, numbness/pain, anxiety, depression and post-traumatic stress disorder. Utilizing the available literature and international disease-specific society guidelines, we constructed symptom-based differential diagnoses, evaluation and management paradigms. This pragmatic, evidence-based consensus document may serve as a guide for a holistic approach to post-COVID neurological care and will complement future clinical trials by outlining best practices in the evaluation and treatment of post-acute neurological signs/symptoms.

Original language	English (US)
Article number	120827
Journal	Journal of the Neurological Sciences
Volume	454
DOIs	https://doi.org/10.1016/j.jns.2023.120827
State	Published - Nov 15 2023

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. JAF reports funding from NIH/NINDS , NIH/NHLBI , NIH/NIA and NIH/NCATS for COVID-19 related research. ASW reports funding by the School of Medicine, Technical University of Munich , Grant Number H.40001.1.7-08 in support of the Global COVID-19 Neuro Research Coalition. We acknowledge the contributions of Erica Westenberg to the coordination of the Global COVID-19 Neuro Research Coalition and the management of the current manuscript.

Keywords

COVID-19
Diagnosis
Evaluation
Management
Neurologic
SARS-COV-2
Therapeutics
Therapy
Treatment

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.1016/j.jns.2023.120827

Cite this

Frontera, J. A., Guekht, A., Allegri, R. F., Ashraf, M., Baykan, B., Crivelli, L., Easton, A., Garcia-Azorin, D., Helbok, R., Joshi, J., Koehn, J., Koralnik, I., Netravathi, M., Michael, B., Nilo, A., Özge, A., Padda, K., Pellitteri, G., Prasad, K., ... Winkler, A. S. (2023). Evaluation and treatment approaches for neurological post-acute sequelae of COVID-19: A consensus statement and scoping review from the global COVID-19 neuro research coalition. Journal of the Neurological Sciences, 454, Article 120827. https://doi.org/10.1016/j.jns.2023.120827

@article{005e9697ddca4c5a98081c064abe1ff1,

title = "Evaluation and treatment approaches for neurological post-acute sequelae of COVID-19: A consensus statement and scoping review from the global COVID-19 neuro research coalition",

abstract = "Post-acute neurological sequelae of COVID-19 affect millions of people worldwide, yet little data is available to guide treatment strategies for the most common symptoms. We conducted a scoping review of PubMed/Medline from 1/1/2020–4/1/2023 to identify studies addressing diagnosis and treatment of the most common post-acute neurological sequelae of COVID-19 including: cognitive impairment, sleep disorders, headache, dizziness/lightheadedness, fatigue, weakness, numbness/pain, anxiety, depression and post-traumatic stress disorder. Utilizing the available literature and international disease-specific society guidelines, we constructed symptom-based differential diagnoses, evaluation and management paradigms. This pragmatic, evidence-based consensus document may serve as a guide for a holistic approach to post-COVID neurological care and will complement future clinical trials by outlining best practices in the evaluation and treatment of post-acute neurological signs/symptoms.",

keywords = "COVID-19, Diagnosis, Evaluation, Management, Neurologic, SARS-COV-2, Therapeutics, Therapy, Treatment",

author = "Frontera, {Jennifer A.} and Alla Guekht and Allegri, {Ricardo F.} and Mariam Ashraf and Bet{\"u}l Baykan and Luc{\'i}a Crivelli and Ava Easton and David Garcia-Azorin and Raimund Helbok and Jatin Joshi and Julia Koehn and Igor Koralnik and M. Netravathi and Benedict Michael and Annacarmen Nilo and Aynur {\"O}zge and Karanbir Padda and Gaia Pellitteri and Kameshwar Prasad and Marina Romozzi and Deanna Saylor and Adam Seed and Kiran Thakur and Derya Uluduz and Alberto Vogrig and Welte, {Tamara M.} and Erica Westenberg and Dmitry Zhuravlev and Mikhail Zinchuk and Winkler, {Andrea S.}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier B.V.",

year = "2023",

month = nov,

day = "15",

doi = "10.1016/j.jns.2023.120827",

language = "English (US)",

volume = "454",

journal = "Journal of the Neurological Sciences",

issn = "0022-510X",

publisher = "Elsevier B.V.",

}

Frontera, JA, Guekht, A, Allegri, RF, Ashraf, M, Baykan, B, Crivelli, L, Easton, A, Garcia-Azorin, D, Helbok, R, Joshi, J, Koehn, J, Koralnik, I, Netravathi, M, Michael, B, Nilo, A, Özge, A, Padda, K, Pellitteri, G, Prasad, K, Romozzi, M, Saylor, D, Seed, A, Thakur, K, Uluduz, D, Vogrig, A, Welte, TM, Westenberg, E, Zhuravlev, D, Zinchuk, M & Winkler, AS 2023, 'Evaluation and treatment approaches for neurological post-acute sequelae of COVID-19: A consensus statement and scoping review from the global COVID-19 neuro research coalition', Journal of the Neurological Sciences, vol. 454, 120827. https://doi.org/10.1016/j.jns.2023.120827

Evaluation and treatment approaches for neurological post-acute sequelae of COVID-19: A consensus statement and scoping review from the global COVID-19 neuro research coalition. / Frontera, Jennifer A.; Guekht, Alla; Allegri, Ricardo F. et al.
In: Journal of the Neurological Sciences, Vol. 454, 120827, 15.11.2023.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Evaluation and treatment approaches for neurological post-acute sequelae of COVID-19

T2 - A consensus statement and scoping review from the global COVID-19 neuro research coalition

AU - Frontera, Jennifer A.

AU - Guekht, Alla

AU - Allegri, Ricardo F.

AU - Ashraf, Mariam

AU - Baykan, Betül

AU - Crivelli, Lucía

AU - Easton, Ava

AU - Garcia-Azorin, David

AU - Helbok, Raimund

AU - Joshi, Jatin

AU - Koehn, Julia

AU - Koralnik, Igor

AU - Netravathi, M.

AU - Michael, Benedict

AU - Nilo, Annacarmen

AU - Özge, Aynur

AU - Padda, Karanbir

AU - Pellitteri, Gaia

AU - Prasad, Kameshwar

AU - Romozzi, Marina

AU - Saylor, Deanna

AU - Seed, Adam

AU - Thakur, Kiran

AU - Uluduz, Derya

AU - Vogrig, Alberto

AU - Welte, Tamara M.

AU - Westenberg, Erica

AU - Zhuravlev, Dmitry

AU - Zinchuk, Mikhail

AU - Winkler, Andrea S.

PY - 2023/11/15

Y1 - 2023/11/15

N2 - Post-acute neurological sequelae of COVID-19 affect millions of people worldwide, yet little data is available to guide treatment strategies for the most common symptoms. We conducted a scoping review of PubMed/Medline from 1/1/2020–4/1/2023 to identify studies addressing diagnosis and treatment of the most common post-acute neurological sequelae of COVID-19 including: cognitive impairment, sleep disorders, headache, dizziness/lightheadedness, fatigue, weakness, numbness/pain, anxiety, depression and post-traumatic stress disorder. Utilizing the available literature and international disease-specific society guidelines, we constructed symptom-based differential diagnoses, evaluation and management paradigms. This pragmatic, evidence-based consensus document may serve as a guide for a holistic approach to post-COVID neurological care and will complement future clinical trials by outlining best practices in the evaluation and treatment of post-acute neurological signs/symptoms.

AB - Post-acute neurological sequelae of COVID-19 affect millions of people worldwide, yet little data is available to guide treatment strategies for the most common symptoms. We conducted a scoping review of PubMed/Medline from 1/1/2020–4/1/2023 to identify studies addressing diagnosis and treatment of the most common post-acute neurological sequelae of COVID-19 including: cognitive impairment, sleep disorders, headache, dizziness/lightheadedness, fatigue, weakness, numbness/pain, anxiety, depression and post-traumatic stress disorder. Utilizing the available literature and international disease-specific society guidelines, we constructed symptom-based differential diagnoses, evaluation and management paradigms. This pragmatic, evidence-based consensus document may serve as a guide for a holistic approach to post-COVID neurological care and will complement future clinical trials by outlining best practices in the evaluation and treatment of post-acute neurological signs/symptoms.

KW - COVID-19

KW - Diagnosis

KW - Evaluation

KW - Management

KW - Neurologic

KW - SARS-COV-2

KW - Therapeutics

KW - Therapy

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=85174851579&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85174851579&partnerID=8YFLogxK

U2 - 10.1016/j.jns.2023.120827

DO - 10.1016/j.jns.2023.120827

M3 - Review article

C2 - 37856998

AN - SCOPUS:85174851579

SN - 0022-510X

VL - 454

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

M1 - 120827

ER -

Evaluation and treatment approaches for neurological post-acute sequelae of COVID-19: A consensus statement and scoping review from the global COVID-19 neuro research coalition

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this