Evaluation of 96‐hour infusion fluorouracil plus cisplatin in combination with alpha interferon for patients with advanced squamous cell carcinoma of the head and neck. A southwest oncology group study

Maha Hussain*, Jacqueline Benedetti, Roy E. Smith, Gladys I. Rodriguez, David Schuller, John Ensley

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Background. Recurrent cancer of the head and neck after primary therapy is almost always fatal. The combination of 5‐fluorouracil (5‐FU) and cisplatin is considered the best available therapy but complete response rates remain too low to affect survival. This study was designed to evaluate the complete response rate and toxicity of 5‐FU, cisplatin, and alpha‐interferon (α‐IFN) in patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN). Methods. Fifty eligible patients with recurrent or metastatic SCCHN and no prior chemotherapy (40 men, 10 women; age range, 26–77 years; median, 59 years; 82% white; 88% had prior surgery and 92% had prior radiation therapy) were treated every 21 days with 96‐bour infusion of 5‐FU 1000 mg/m2/day; cisplatin 100 mg/m2, day 1; and α‐IFN 5 × 106 units/day, days 1–4. Results. One hundred fifty‐seven courses of chemotherapy were administered, with a median of three courses. Thirty‐seven patients experienced Grade 3 or 4 toxicity. Of the 17 patients with Grade 4 toxicity; 12 had hematologic toxicity, 3 stomatitis, and 2 vomiting. Two additional patients died of myelosuppression‐related sepsis. Of the 50 patients, 3 (6%) achieved a complete response, five (10%) had a partial response, 3 (6%) had unconfirmed response (1 complete and 2 partial), 10 (20%) had stable disease, 17 (34%) progressed, and 12 (24%) were considered nonresponders owing to early death (6) or inadequate assessment (6). The median survival was 5 months. Conclusion. The complete response rate of patients with recurrent or metastatic SCCHN treated with 5‐FU, cisplatin, and α‐IFN does not appear to be superior to that observed for 5‐FU and cisplatin. Alpha‐interferon appears to augment hematologic and gastrointestinal toxicities associated with this combination.

Original languageEnglish (US)
Pages (from-to)1233-1237
Number of pages5
JournalCancer
Volume76
Issue number7
DOIs
StatePublished - Oct 1 1995

Keywords

  • biomodulation
  • chemotherapy
  • recurrent head and neck cancer
  • α‐interferon

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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