Evaluation of a needle disinfectant technique to reduce infection-related hospitalisation after transrectal prostate biopsy

the Michigan Urological Surgery Improvement Collaborative

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Objectives: To determine whether a needle disinfectant step during transrectal ultrasonography (TRUS)-guided prostate biopsy is associated with lower rates of infection-related hospitalisation. Patients and Methods: We conducted a retrospective analysis of all TRUS-guided prostate biopsies taken across the Michigan Urological Surgery Improvement Collaborative (MUSIC) from January 2012 to March 2015. Natural variation in technique allowed us to evaluate for differences in infection-related hospitalisations based on whether or not a needle disinfectant technique was used. The disinfectant technique was an intra-procedural step to cleanse the biopsy needle with antibacterial solution after each core was sampled (i.e., 10% formalin or 70% isopropyl alcohol). After grouping biopsies according to whether or not the procedure included a needle disinfectant step, we compared the rate of infection-related hospitalisations within 30 days of biopsy. Generalised estimating equation models were fit to adjust for potential confounders. Results: During the evaluated period, 17 954 TRUS-guided prostate biopsies were taken with 5 321 (29.6%) including a disinfectant step. The observed rate of infection-related hospitalisation was lower when a disinfectant technique was used during biopsy (0.60% vs 0.90%; P = 0.04). After accounting for differences between groups the adjusted hospitalisation rate in the disinfectant group was 0.85% vs 1.12% in the no disinfectant group (adjusted odds ratio 0.76, 95% confidence interval 0.50–1.15; P = 0.19). Conclusions: In this observational analysis, hospitalisations for infectious complications were less common when the TRUS-guided prostate biopsy included a needle disinfection step. However, after adjusting for potential confounders the effect of needle disinfection was not statistically significant. Prospective evaluation is warranted to determine if this step provides a scalable and effective method to minimise infectious complications.

Original languageEnglish (US)
Pages (from-to)232-238
Number of pages7
JournalBJU International
Issue number2
StatePublished - Feb 1 2018


  • infection
  • prostate biopsy
  • prostate cancer
  • quality improvement

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Evaluation of a needle disinfectant technique to reduce infection-related hospitalisation after transrectal prostate biopsy'. Together they form a unique fingerprint.

Cite this