Evaluation of dynamic balancing randomization method in clinical trials

Chun Fang Wu, Jin Fang Xu, Jian Lu, Mei Jing Wu, Jia He*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Dynamic balance randomization (DBR) has rarely been used in randomized controlled clinical trial. This article aimed to introduce this new allocation method and evaluate its allocation balance and randomness to promote the use of this method. We evaluated the balance of the allocation groups of all the 4 allocation methods in simulated trials with various sample size and prognostic factors and the chances of random allocation of DBR method. Through the allocation process of DBR method, the treatment groups were the most balance of all methods both within and among the prognostic factors. Dynamic balancing randomization is a flexible method with both balance and randomness and suitable for trials with small sample size, strict blindness that needed rigorous balance.

Original languageEnglish (US)
Pages (from-to)590-593
Number of pages4
JournalChinese Journal of New Drugs
Volume20
Issue number7
StatePublished - 2011

Keywords

  • Balance
  • Dynamic balancing randomization
  • Monte-Carlo simulation
  • Randomness

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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