Model systems that evaluated different approaches to construct the central ether ring of maoecrystal V are described. Our first model systems attempted the ether formation using C-H functionalization reactions, which led to interesting rearrangements but none of the desired ether product. An intramolecular conjugate addition strategy was then explored that successfully formed the targeted C-O bond but resulted in the undesired stereochemistry.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Feb 13 2013|
- Maoecrystal V
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry