Evaluation of human polyomavirus BK as a potential cause of villitis of unknown etiology and spontaneous abortion

Mariana M. Cajaiba; W. T. Parks; K. Fuhrer; P. S. Randhawa

doi:10.1002/jmv.22082

Evaluation of human polyomavirus BK as a potential cause of villitis of unknown etiology and spontaneous abortion

Mariana M. Cajaiba^*, W. T. Parks, K. Fuhrer, P. S. Randhawa

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Polyomavirus BK (BKV) is a widely latent pathogen in man. Although viral reactivation during pregnancy has been demonstrated, and polyomaviruses have been linked to chromosomal abnormalities, a pathogenic role for BKV in fetoplacental disease has not been explored. We performed in situ hybridization studies with BKV probes on cases of villitis of unknown etiology (102), diffuse villitis (25), and spontaneous abortion (22). We found no evidence that BKV plays a role in the pathogenesis of these common fetoplacental disorders.

Original language	English (US)
Pages (from-to)	1031-1033
Number of pages	3
Journal	Journal of Medical Virology
Volume	83
Issue number	6
DOIs	https://doi.org/10.1002/jmv.22082
State	Published - Jun 1 2011

Keywords

BK virus
Chronic villitis of unknown etiology
Fetoplacental disorders
In situ hybridization

ASJC Scopus subject areas

Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jmv.22082

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title = "Evaluation of human polyomavirus BK as a potential cause of villitis of unknown etiology and spontaneous abortion",

abstract = "Polyomavirus BK (BKV) is a widely latent pathogen in man. Although viral reactivation during pregnancy has been demonstrated, and polyomaviruses have been linked to chromosomal abnormalities, a pathogenic role for BKV in fetoplacental disease has not been explored. We performed in situ hybridization studies with BKV probes on cases of villitis of unknown etiology (102), diffuse villitis (25), and spontaneous abortion (22). We found no evidence that BKV plays a role in the pathogenesis of these common fetoplacental disorders.",

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AU - Cajaiba, Mariana M.

AU - Parks, W. T.

AU - Fuhrer, K.

AU - Randhawa, P. S.

PY - 2011/6/1

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N2 - Polyomavirus BK (BKV) is a widely latent pathogen in man. Although viral reactivation during pregnancy has been demonstrated, and polyomaviruses have been linked to chromosomal abnormalities, a pathogenic role for BKV in fetoplacental disease has not been explored. We performed in situ hybridization studies with BKV probes on cases of villitis of unknown etiology (102), diffuse villitis (25), and spontaneous abortion (22). We found no evidence that BKV plays a role in the pathogenesis of these common fetoplacental disorders.

AB - Polyomavirus BK (BKV) is a widely latent pathogen in man. Although viral reactivation during pregnancy has been demonstrated, and polyomaviruses have been linked to chromosomal abnormalities, a pathogenic role for BKV in fetoplacental disease has not been explored. We performed in situ hybridization studies with BKV probes on cases of villitis of unknown etiology (102), diffuse villitis (25), and spontaneous abortion (22). We found no evidence that BKV plays a role in the pathogenesis of these common fetoplacental disorders.

KW - BK virus

KW - Chronic villitis of unknown etiology

KW - Fetoplacental disorders

KW - In situ hybridization

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Evaluation of human polyomavirus BK as a potential cause of villitis of unknown etiology and spontaneous abortion

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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