Evaluation of human polyomavirus BK as a potential cause of villitis of unknown etiology and spontaneous abortion

Mariana M. Cajaiba*, W. T. Parks, K. Fuhrer, P. S. Randhawa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Polyomavirus BK (BKV) is a widely latent pathogen in man. Although viral reactivation during pregnancy has been demonstrated, and polyomaviruses have been linked to chromosomal abnormalities, a pathogenic role for BKV in fetoplacental disease has not been explored. We performed in situ hybridization studies with BKV probes on cases of villitis of unknown etiology (102), diffuse villitis (25), and spontaneous abortion (22). We found no evidence that BKV plays a role in the pathogenesis of these common fetoplacental disorders.

Original languageEnglish (US)
Pages (from-to)1031-1033
Number of pages3
JournalJournal of Medical Virology
Volume83
Issue number6
DOIs
StatePublished - Jun 1 2011

Keywords

  • BK virus
  • Chronic villitis of unknown etiology
  • Fetoplacental disorders
  • In situ hybridization

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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