Evaluation of hydroxylapatite graft materials in canine cervical spine fusions

Stephen D. Cook*, Mary C. Reynolds, Thomas S. Whitecloud, Alan S. Routman, Amanda F. Harding, John F. Kay, Michael Jarcho

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


The efficacy of ceramic hydroxylapatite implant materials as graft materials for cervical spine fusion was evaluated in canines. Bioresorbable and non-bioresorbable systems were evaluated at time periods ranging from 1 to 24 weeks. Implant interbody position and progression of fusion were evaluated radiographically and histologically. Implant fracture and extrusion into adjacent soft tissues occurred in nine of 23 cases. Implant fracture occurred in many of the remaining 14 cases, however, the implant materials remained within the interspace. Implant fracture occurred with both implant systems. Radiographically little evidence of fusion was observed at less than 6 weeks, however by 12 weeks evidence of fusion was noted and was confirmed histologically. No difference in fusion rate or degree of fusion was observed between the two implant systems.

Original languageEnglish (US)
Pages (from-to)305-309
Number of pages5
Issue number4
StatePublished - May 1986


  • Cervical spine
  • Hydroxylapatite
  • Interbody fusion

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Clinical Neurology


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