Evaluation of Modified Look-Locker Inversion Recovery and Arrhythmia-Insensitive Rapid Cardiac T1 Mapping Pulse Sequences in Cardiomyopathy Patients

Sean Robison*, Kyungpyo Hong, Daniel Kim, Rachel Lloyd, Jay Ramchand, Emma Hornsey, Piyush Srivastava, Gerard Smith, Leighton Kearney, Ruth Lim

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Objective The aim of this study was to compare the performance of arrhythmia-insensitive rapid (AIR) and modified Look-Locker inversion recovery (MOLLI) T1 mapping in patients with cardiomyopathies. Methods In 58 patients referred for clinical cardiac magnetic resonance imaging at 1.5 T, we compared MOLLI and AIR native and postcontrast T1 measurements. Two readers independently analyzed myocardial and blood T1 values. Agreement between techniques, interreader agreement per technique, and intrascan agreement per technique were evaluated. Results The MOLLI and AIR T1 values were strongly correlated (r2 = 0.98); however, statistically significantly different T1 values were derived (bias 80 milliseconds, pooled data, P < 0.01). Both techniques demonstrated high repeatability (MOLLI, r2 = 1.00 and coefficient of repeatability [CR] = 72 milliseconds; AIR, r2 = 0.99 and CR = 184.2 milliseconds) and produced high interreader agreement (MOLLI, r2 = 1.00 and CR = 51.7 milliseconds; AIR, r2 = 0.99 and CR = 183.5 milliseconds). Conclusions Arrhythmia-insensitive rapid and MOLLI sequences produced significantly different T1 values in a diverse patient cohort.

Original languageEnglish (US)
Pages (from-to)732-738
Number of pages7
JournalJournal of Computer Assisted Tomography
Volume42
Issue number5
DOIs
StatePublished - Sep 1 2018

Keywords

  • MOLLI
  • MRI
  • T1 mapping
  • arrhythmia-insensitive rapid
  • cardiac

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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