Evaluation of Modified Look-Locker Inversion Recovery and Arrhythmia-Insensitive Rapid Cardiac T1 Mapping Pulse Sequences in Cardiomyopathy Patients

Sean Robison; Kyungpyo Hong; Daniel Kim; Rachel Lloyd; Jay Ramchand; Emma Hornsey; Piyush Srivastava; Gerard Smith; Leighton Kearney; Ruth Lim

doi:10.1097/RCT.0000000000000746

Evaluation of Modified Look-Locker Inversion Recovery and Arrhythmia-Insensitive Rapid Cardiac T1 Mapping Pulse Sequences in Cardiomyopathy Patients

Sean Robison^*, Kyungpyo Hong, Daniel Kim, Rachel Lloyd, Jay Ramchand, Emma Hornsey, Piyush Srivastava, Gerard Smith, Leighton Kearney, Ruth Lim

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Objective The aim of this study was to compare the performance of arrhythmia-insensitive rapid (AIR) and modified Look-Locker inversion recovery (MOLLI) T1 mapping in patients with cardiomyopathies. Methods In 58 patients referred for clinical cardiac magnetic resonance imaging at 1.5 T, we compared MOLLI and AIR native and postcontrast T1 measurements. Two readers independently analyzed myocardial and blood T1 values. Agreement between techniques, interreader agreement per technique, and intrascan agreement per technique were evaluated. Results The MOLLI and AIR T1 values were strongly correlated (r² = 0.98); however, statistically significantly different T1 values were derived (bias 80 milliseconds, pooled data, P < 0.01). Both techniques demonstrated high repeatability (MOLLI, r² = 1.00 and coefficient of repeatability [CR] = 72 milliseconds; AIR, r² = 0.99 and CR = 184.2 milliseconds) and produced high interreader agreement (MOLLI, r² = 1.00 and CR = 51.7 milliseconds; AIR, r² = 0.99 and CR = 183.5 milliseconds). Conclusions Arrhythmia-insensitive rapid and MOLLI sequences produced significantly different T1 values in a diverse patient cohort.

Original language	English (US)
Pages (from-to)	732-738
Number of pages	7
Journal	Journal of Computer Assisted Tomography
Volume	42
Issue number	5
DOIs	https://doi.org/10.1097/RCT.0000000000000746
State	Published - Sep 1 2018

Funding

From the *Department of Radiology, Austin Hospital, Austin Health (Department Affiliated With The University of Melbourne, Melbourne Medical School), Heidelberg, Victoria, Australia; †Department of Radiology, Northwestern University, Chicago, IL; and ‡Department of Cardiology, St Vincent's Hospital, Melbourne; §Department of Medicine, The University of Melbourne, Austin Health, Heidelberg; and ||Departments of Radiology and Surgery, The University of Melbourne, Parkville, Victoria, Australia. Received for publication August 30, 2017; accepted February 12, 2018. Correspondence to: Sean Robison, MBBS, PO Box 3024, Manuka, Australian Capital Territory, Australia 2603 (e‐mail: [email protected]). Support was provided by the National Institutes of Health (R01HL116895, R01HL138578, R21EB024315, R21AG055954). The authors declare no conflict of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved. DOI: 10.1097/RCT.0000000000000746

Keywords

MOLLI
MRI
T1 mapping
arrhythmia-insensitive rapid
cardiac

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1097/RCT.0000000000000746

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Robison, S., Hong, K., Kim, D., Lloyd, R., Ramchand, J., Hornsey, E., Srivastava, P., Smith, G., Kearney, L., & Lim, R. (2018). Evaluation of Modified Look-Locker Inversion Recovery and Arrhythmia-Insensitive Rapid Cardiac T1 Mapping Pulse Sequences in Cardiomyopathy Patients. Journal of Computer Assisted Tomography, 42(5), 732-738. https://doi.org/10.1097/RCT.0000000000000746

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title = "Evaluation of Modified Look-Locker Inversion Recovery and Arrhythmia-Insensitive Rapid Cardiac T1 Mapping Pulse Sequences in Cardiomyopathy Patients",

abstract = "Objective The aim of this study was to compare the performance of arrhythmia-insensitive rapid (AIR) and modified Look-Locker inversion recovery (MOLLI) T1 mapping in patients with cardiomyopathies. Methods In 58 patients referred for clinical cardiac magnetic resonance imaging at 1.5 T, we compared MOLLI and AIR native and postcontrast T1 measurements. Two readers independently analyzed myocardial and blood T1 values. Agreement between techniques, interreader agreement per technique, and intrascan agreement per technique were evaluated. Results The MOLLI and AIR T1 values were strongly correlated (r2 = 0.98); however, statistically significantly different T1 values were derived (bias 80 milliseconds, pooled data, P < 0.01). Both techniques demonstrated high repeatability (MOLLI, r2 = 1.00 and coefficient of repeatability [CR] = 72 milliseconds; AIR, r2 = 0.99 and CR = 184.2 milliseconds) and produced high interreader agreement (MOLLI, r2 = 1.00 and CR = 51.7 milliseconds; AIR, r2 = 0.99 and CR = 183.5 milliseconds). Conclusions Arrhythmia-insensitive rapid and MOLLI sequences produced significantly different T1 values in a diverse patient cohort.",

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author = "Sean Robison and Kyungpyo Hong and Daniel Kim and Rachel Lloyd and Jay Ramchand and Emma Hornsey and Piyush Srivastava and Gerard Smith and Leighton Kearney and Ruth Lim",

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Robison, S, Hong, K , Kim, D, Lloyd, R, Ramchand, J, Hornsey, E, Srivastava, P, Smith, G, Kearney, L & Lim, R 2018, 'Evaluation of Modified Look-Locker Inversion Recovery and Arrhythmia-Insensitive Rapid Cardiac T1 Mapping Pulse Sequences in Cardiomyopathy Patients', Journal of Computer Assisted Tomography, vol. 42, no. 5, pp. 732-738. https://doi.org/10.1097/RCT.0000000000000746

TY - JOUR

T1 - Evaluation of Modified Look-Locker Inversion Recovery and Arrhythmia-Insensitive Rapid Cardiac T1 Mapping Pulse Sequences in Cardiomyopathy Patients

AU - Robison, Sean

AU - Hong, Kyungpyo

AU - Kim, Daniel

AU - Lloyd, Rachel

AU - Ramchand, Jay

AU - Hornsey, Emma

AU - Srivastava, Piyush

AU - Smith, Gerard

AU - Kearney, Leighton

AU - Lim, Ruth

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Objective The aim of this study was to compare the performance of arrhythmia-insensitive rapid (AIR) and modified Look-Locker inversion recovery (MOLLI) T1 mapping in patients with cardiomyopathies. Methods In 58 patients referred for clinical cardiac magnetic resonance imaging at 1.5 T, we compared MOLLI and AIR native and postcontrast T1 measurements. Two readers independently analyzed myocardial and blood T1 values. Agreement between techniques, interreader agreement per technique, and intrascan agreement per technique were evaluated. Results The MOLLI and AIR T1 values were strongly correlated (r2 = 0.98); however, statistically significantly different T1 values were derived (bias 80 milliseconds, pooled data, P < 0.01). Both techniques demonstrated high repeatability (MOLLI, r2 = 1.00 and coefficient of repeatability [CR] = 72 milliseconds; AIR, r2 = 0.99 and CR = 184.2 milliseconds) and produced high interreader agreement (MOLLI, r2 = 1.00 and CR = 51.7 milliseconds; AIR, r2 = 0.99 and CR = 183.5 milliseconds). Conclusions Arrhythmia-insensitive rapid and MOLLI sequences produced significantly different T1 values in a diverse patient cohort.

AB - Objective The aim of this study was to compare the performance of arrhythmia-insensitive rapid (AIR) and modified Look-Locker inversion recovery (MOLLI) T1 mapping in patients with cardiomyopathies. Methods In 58 patients referred for clinical cardiac magnetic resonance imaging at 1.5 T, we compared MOLLI and AIR native and postcontrast T1 measurements. Two readers independently analyzed myocardial and blood T1 values. Agreement between techniques, interreader agreement per technique, and intrascan agreement per technique were evaluated. Results The MOLLI and AIR T1 values were strongly correlated (r2 = 0.98); however, statistically significantly different T1 values were derived (bias 80 milliseconds, pooled data, P < 0.01). Both techniques demonstrated high repeatability (MOLLI, r2 = 1.00 and coefficient of repeatability [CR] = 72 milliseconds; AIR, r2 = 0.99 and CR = 184.2 milliseconds) and produced high interreader agreement (MOLLI, r2 = 1.00 and CR = 51.7 milliseconds; AIR, r2 = 0.99 and CR = 183.5 milliseconds). Conclusions Arrhythmia-insensitive rapid and MOLLI sequences produced significantly different T1 values in a diverse patient cohort.

KW - MOLLI

KW - MRI

KW - T1 mapping

KW - arrhythmia-insensitive rapid

KW - cardiac

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Evaluation of Modified Look-Locker Inversion Recovery and Arrhythmia-Insensitive Rapid Cardiac T1 Mapping Pulse Sequences in Cardiomyopathy Patients

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