Abstract
According to the World Health Organization (WHO), in 2010 hearing loss affected more than 278 million people worldwide. The loss of hearing and communication has significant consequences on the emotional well-being of each affected individual. The estimated socio-economic impact is about $100 billion in unrealized household income per year. Despite this impact on society, no Food and Drug Administration (FDA) approved drug intervention is available today that would either protect or reverse the effects of hearing loss. A limiting factor for all efforts to validate drugs for treatment relates to the time consuming animal experiments and subsequent histology. Here, we present an imaging method that is superior to current gold standard methods in flexibility and time for evaluation of histology. Tissue processing times are reduced from weeks to hours. As an example, we show that Brain Derived Neurotrophic Factor (BDNF) reduces the effect of noise induced hearing loss.
| Original language | English (US) |
|---|---|
| Title of host publication | Developments in X-Ray Tomography IX |
| Editors | Stuart R. Stock |
| Publisher | SPIE |
| Volume | 9212 |
| ISBN (Electronic) | 9781628412390 |
| DOIs | |
| State | Published - Jan 1 2014 |
| Event | Developments in X-Ray Tomography IX - San Diego, United States Duration: Aug 18 2014 → Aug 20 2014 |
Other
| Other | Developments in X-Ray Tomography IX |
|---|---|
| Country | United States |
| City | San Diego |
| Period | 8/18/14 → 8/20/14 |
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Keywords
- Imaging
- Neuron counts
- Synchrotron
- X-rays
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Computer Science Applications
- Applied Mathematics
- Electrical and Electronic Engineering
Cite this
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Evaluation of neural cochlear structures after noise trauma using X-ray tomography. / Richter, Claus-Peter; Liddy, Whitney Elizabeth; Vo, Amanda; Young, Hunter; Stock, Stuart R; Xiao, Xianghui; Whitlon, Donna S.
Developments in X-Ray Tomography IX. ed. / Stuart R. Stock. Vol. 9212 SPIE, 2014. 92120U.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - GEN
T1 - Evaluation of neural cochlear structures after noise trauma using X-ray tomography
AU - Richter, Claus-Peter
AU - Liddy, Whitney Elizabeth
AU - Vo, Amanda
AU - Young, Hunter
AU - Stock, Stuart R
AU - Xiao, Xianghui
AU - Whitlon, Donna S
PY - 2014/1/1
Y1 - 2014/1/1
N2 - According to the World Health Organization (WHO), in 2010 hearing loss affected more than 278 million people worldwide. The loss of hearing and communication has significant consequences on the emotional well-being of each affected individual. The estimated socio-economic impact is about $100 billion in unrealized household income per year. Despite this impact on society, no Food and Drug Administration (FDA) approved drug intervention is available today that would either protect or reverse the effects of hearing loss. A limiting factor for all efforts to validate drugs for treatment relates to the time consuming animal experiments and subsequent histology. Here, we present an imaging method that is superior to current gold standard methods in flexibility and time for evaluation of histology. Tissue processing times are reduced from weeks to hours. As an example, we show that Brain Derived Neurotrophic Factor (BDNF) reduces the effect of noise induced hearing loss.
AB - According to the World Health Organization (WHO), in 2010 hearing loss affected more than 278 million people worldwide. The loss of hearing and communication has significant consequences on the emotional well-being of each affected individual. The estimated socio-economic impact is about $100 billion in unrealized household income per year. Despite this impact on society, no Food and Drug Administration (FDA) approved drug intervention is available today that would either protect or reverse the effects of hearing loss. A limiting factor for all efforts to validate drugs for treatment relates to the time consuming animal experiments and subsequent histology. Here, we present an imaging method that is superior to current gold standard methods in flexibility and time for evaluation of histology. Tissue processing times are reduced from weeks to hours. As an example, we show that Brain Derived Neurotrophic Factor (BDNF) reduces the effect of noise induced hearing loss.
KW - Imaging
KW - Neuron counts
KW - Synchrotron
KW - X-rays
UR - http://www.scopus.com/inward/record.url?scp=84922984659&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922984659&partnerID=8YFLogxK
U2 - 10.1117/12.2062385
DO - 10.1117/12.2062385
M3 - Conference contribution
VL - 9212
BT - Developments in X-Ray Tomography IX
A2 - Stock, Stuart R.
PB - SPIE
ER -