Evaluation of neural cochlear structures after noise trauma using X-ray tomography

Claus-Peter Richter, Whitney Elizabeth Liddy, Amanda Vo, Hunter Young, Stuart R Stock, Xianghui Xiao, Donna S Whitlon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

According to the World Health Organization (WHO), in 2010 hearing loss affected more than 278 million people worldwide. The loss of hearing and communication has significant consequences on the emotional well-being of each affected individual. The estimated socio-economic impact is about $100 billion in unrealized household income per year. Despite this impact on society, no Food and Drug Administration (FDA) approved drug intervention is available today that would either protect or reverse the effects of hearing loss. A limiting factor for all efforts to validate drugs for treatment relates to the time consuming animal experiments and subsequent histology. Here, we present an imaging method that is superior to current gold standard methods in flexibility and time for evaluation of histology. Tissue processing times are reduced from weeks to hours. As an example, we show that Brain Derived Neurotrophic Factor (BDNF) reduces the effect of noise induced hearing loss.

Original languageEnglish (US)
Title of host publicationDevelopments in X-Ray Tomography IX
EditorsStuart R. Stock
PublisherSPIE
Volume9212
ISBN (Electronic)9781628412390
DOIs
StatePublished - Jan 1 2014
EventDevelopments in X-Ray Tomography IX - San Diego, United States
Duration: Aug 18 2014Aug 20 2014

Other

OtherDevelopments in X-Ray Tomography IX
CountryUnited States
CitySan Diego
Period8/18/148/20/14

Fingerprint

X-ray Tomography
auditory defects
Audition
Tomography
histology
tomography
Histology
X rays
Drugs
evaluation
Evaluation
drugs
economic impact
income
x rays
hearing
health
brain
animals
Brain-Derived Neurotrophic Factor

Keywords

  • Imaging
  • Neuron counts
  • Synchrotron
  • X-rays

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Richter, C-P., Liddy, W. E., Vo, A., Young, H., Stock, S. R., Xiao, X., & Whitlon, D. S. (2014). Evaluation of neural cochlear structures after noise trauma using X-ray tomography. In S. R. Stock (Ed.), Developments in X-Ray Tomography IX (Vol. 9212). [92120U] SPIE. https://doi.org/10.1117/12.2062385
Richter, Claus-Peter ; Liddy, Whitney Elizabeth ; Vo, Amanda ; Young, Hunter ; Stock, Stuart R ; Xiao, Xianghui ; Whitlon, Donna S. / Evaluation of neural cochlear structures after noise trauma using X-ray tomography. Developments in X-Ray Tomography IX. editor / Stuart R. Stock. Vol. 9212 SPIE, 2014.
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Richter, C-P, Liddy, WE, Vo, A, Young, H, Stock, SR, Xiao, X & Whitlon, DS 2014, Evaluation of neural cochlear structures after noise trauma using X-ray tomography. in SR Stock (ed.), Developments in X-Ray Tomography IX. vol. 9212, 92120U, SPIE, Developments in X-Ray Tomography IX, San Diego, United States, 8/18/14. https://doi.org/10.1117/12.2062385

Evaluation of neural cochlear structures after noise trauma using X-ray tomography. / Richter, Claus-Peter; Liddy, Whitney Elizabeth; Vo, Amanda; Young, Hunter; Stock, Stuart R; Xiao, Xianghui; Whitlon, Donna S.

Developments in X-Ray Tomography IX. ed. / Stuart R. Stock. Vol. 9212 SPIE, 2014. 92120U.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Richter C-P, Liddy WE, Vo A, Young H, Stock SR, Xiao X et al. Evaluation of neural cochlear structures after noise trauma using X-ray tomography. In Stock SR, editor, Developments in X-Ray Tomography IX. Vol. 9212. SPIE. 2014. 92120U https://doi.org/10.1117/12.2062385