Evaluation of neural cochlear structures after noise trauma using X-ray tomography

Claus Peter Richter, Whitney Liddy, Amanda Vo, Hunter Young, Stuart Stock, Xianghui Xiao, Donna Whitlon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations


According to the World Health Organization (WHO), in 2010 hearing loss affected more than 278 million people worldwide. The loss of hearing and communication has significant consequences on the emotional well-being of each affected individual. The estimated socio-economic impact is about $100 billion in unrealized household income per year. Despite this impact on society, no Food and Drug Administration (FDA) approved drug intervention is available today that would either protect or reverse the effects of hearing loss. A limiting factor for all efforts to validate drugs for treatment relates to the time consuming animal experiments and subsequent histology. Here, we present an imaging method that is superior to current gold standard methods in flexibility and time for evaluation of histology. Tissue processing times are reduced from weeks to hours. As an example, we show that Brain Derived Neurotrophic Factor (BDNF) reduces the effect of noise induced hearing loss.

Original languageEnglish (US)
Title of host publicationDevelopments in X-Ray Tomography IX
EditorsStuart R. Stock
ISBN (Electronic)9781628412390
StatePublished - 2014
EventDevelopments in X-Ray Tomography IX - San Diego, United States
Duration: Aug 18 2014Aug 20 2014

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X


OtherDevelopments in X-Ray Tomography IX
Country/TerritoryUnited States
CitySan Diego


  • Imaging
  • Neuron counts
  • Synchrotron
  • X-rays

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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