Evaluation of pan-Immuno-Inflammation value for In-hospital mortality in acute pulmonary embolism patients

Vedat Çiçek, Samet Yavuz, Faysal Şaylık, Şölen Taşlıçukur, Ahmet Öz, Mert Babaoğlu, Almina Erdem, İrem Yılmaz, Ulas Bagci, Tufan Cinar

Research output: Contribution to journalArticlepeer-review


Background: Pan-immuno-inflammation value (PIV) is a new and comprehensive index that reflects both the immune response and systemic inflammation in the body. Objective: The aim of this study was to investigate the prognostic relevance of PIV in predicting in-hospital mortality in acute pulmonary embolism (PE) patients and to compare it with the well-known risk scoring system, PE severity index (PESI), which is commonly used for a short-term mortality prediction in such patients. Methods: In total, 373 acute PE patients diagnosed with contrast-enhanced computed tomography were included in the study. Detailed cardiac evaluation of each patient was performed and PESI and PIV were calculated. Results: In total, 60 patients died during their hospital stay. The multivariable logistic regression analysis revealed that baseline heart rate, N-terminal pro-B-type natriuretic peptide, lactate dehydrogenase, PIV, and PESI were independent risk factors for in-hospital mortality in acute PE patients. When comparing with PESI, PIV was non-inferior in terms of predicting the survival status in patients with acute PE. Conclusion: In our study, we found that the PIV was statistically significant in predicting in-hospital mortality in acute PE patients and was non-inferior to the PESI.

Original languageEnglish (US)
Pages (from-to)65-79
Number of pages15
JournalRevista de Investigacion Clinica
Issue number2
StatePublished - Feb 15 2024


  • Acute pulmonary embolism
  • In-hospitalmortality
  • Pan-immuno-inflammation value
  • Pulmonary embolism severity index

ASJC Scopus subject areas

  • General Medicine

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