Evaluation of pediatric epigenetic clocks across multiple tissues

on behalf of program collaborators for Environmental influences on Child Health Outcomes

doi:10.1186/s13148-023-01552-3

Evaluation of pediatric epigenetic clocks across multiple tissues

on behalf of program collaborators for Environmental influences on Child Health Outcomes

Medical Social Sciences

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Background: Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination. Results: Our study used data from seven tissue types on three DNA methylation profiling microarrays and found that the Knight and Bohlin clocks performed similarly for blood cells, while the Lee clock was superior for placental samples. The pediatric-buccal-epigenetic clock performed the best for pediatric buccal samples, while the Horvath clock is recommended for children's blood cell samples. The NeoAge clock stands out for its unique ability to predict post-menstrual age with high correlation with the observed age in infant buccal cell samples. Conclusions: Our findings provide valuable guidance for future research and development of epigenetic clocks in pediatric samples, enabling more accurate assessments of biological age.

Original language	English (US)
Article number	142
Journal	Clinical Epigenetics
Volume	15
Issue number	1
DOIs	https://doi.org/10.1186/s13148-023-01552-3
State	Published - Dec 2023

Funding

The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Research reported in this publication was supported by the Environmental influences on Child Health Outcomes (ECHO) program, Office of the Director, National Institutes of Health, under Award Numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 with co-funding from the Office of Behavioral and Social Science Research (PRO Core). The following grants supported data collection: Project Viva is supported by NIH UH3OD023286 (Oken) and R01HD034568; The Healthy Start Study is funded by the National Institutes of Health (NIH) R01DK076648 and UH3OD023248 (Dabelea). The URECA studies are supported by NIH grants UG3/UH3OD023282 (Gern), UM1 AI114271, and UM1 AI160040; ARCH is supported by NIH UG3OD023285 and UH3OD023285 (Kerver); MADRES is supported by UH3OD023287 (Breton); ECHO-NOVI is supported by R01HD072267, UG3OD023347, UH3OD023347 (Lester), and R01HD084515; UH3OD023318 (Dunlop), R01MD009064 (Smith/Dunlop). UH3OD023253(Camargo); UH3OD023275(Karagas); UH3OD023271(Karr); UH3OD023288(McEvoy); UH3OD023342(Lyall); UH3OD023348 (O’Shea); UH3OD023290 (Herbstman) and UH3OD023305 (Trasande). Dr. Perng is supported by the Center for Clinical and Translational Sciences Institute KL2-TR002534 and ADA-7-22-ICTSPM-08.

Keywords

DNA methylation
Early childhood chronological age
Epigenetic clock
Gestational age

ASJC Scopus subject areas

Molecular Biology
Genetics
Developmental Biology
Genetics(clinical)

Access to Document

10.1186/s13148-023-01552-3

Cite this

@article{4c8bce5070cc4e4faa446986b632d7ec,

title = "Evaluation of pediatric epigenetic clocks across multiple tissues",

abstract = "Background: Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination. Results: Our study used data from seven tissue types on three DNA methylation profiling microarrays and found that the Knight and Bohlin clocks performed similarly for blood cells, while the Lee clock was superior for placental samples. The pediatric-buccal-epigenetic clock performed the best for pediatric buccal samples, while the Horvath clock is recommended for children's blood cell samples. The NeoAge clock stands out for its unique ability to predict post-menstrual age with high correlation with the observed age in infant buccal cell samples. Conclusions: Our findings provide valuable guidance for future research and development of epigenetic clocks in pediatric samples, enabling more accurate assessments of biological age.",

keywords = "DNA methylation, Early childhood chronological age, Epigenetic clock, Gestational age",

author = "{on behalf of program collaborators for Environmental influences on Child Health Outcomes} and Fang Fang and Linran Zhou and Wei Perng and Marsit, {Carmen J.} and Knight, {Anna K.} and Andres Cardenas and Aung, {Max T.} and Hivert, {Marie France} and Aris, {Izzuddin M.} and Goodrich, {Jaclyn M.} and Smith, {Alicia K.} and Abigail Gaylord and Fry, {Rebecca C.} and Emily Oken and George O{\textquoteright}Connor and Ruden, {Douglas M.} and Leonardo Trasande and Herbstman, {Julie B.} and Camargo, {Carlos A.} and Bush, {Nicole R.} and Dunlop, {Anne L.} and Dabelea, {Dana M.} and Karagas, {Margaret R.} and Breton, {Carrie V.} and Carole Ober and Everson, {Todd M.} and Page, {Grier P.} and Christine Ladd-Acosta and Smith, {P. B.} and Newby, {L. K.} and Jacobson, {L. P.} and Catellier, {D. J.} and R. Gershon and D. Cella and Laham, {F. R.} and Mansbach, {J. M.} and S. Wu and Spergel, {J. M.} and Celed{\'o}n, {J. C.} and Puls, {H. T.} and Teach, {S. J.} and Porter, {S. C.} and Waynik, {I. Y.} and Iyer, {S. S.} and Samuels-Kalow, {M. E.} and A. D.Thompson and Stevenson, {M. D.} and Bauer, {C. S.} and Inhofe, {N. R.} and M. Boos",

note = "Publisher Copyright: {\textcopyright} 2023, BioMed Central Ltd., part of Springer Nature.",

year = "2023",

month = dec,

doi = "10.1186/s13148-023-01552-3",

language = "English (US)",

volume = "15",

journal = "Clinical Epigenetics",

issn = "1868-7075",

publisher = "BioMed Central Ltd.",

number = "1",

}

TY - JOUR

T1 - Evaluation of pediatric epigenetic clocks across multiple tissues

AU - on behalf of program collaborators for Environmental influences on Child Health Outcomes

AU - Fang, Fang

AU - Zhou, Linran

AU - Perng, Wei

AU - Marsit, Carmen J.

AU - Knight, Anna K.

AU - Cardenas, Andres

AU - Aung, Max T.

AU - Hivert, Marie France

AU - Aris, Izzuddin M.

AU - Goodrich, Jaclyn M.

AU - Smith, Alicia K.

AU - Gaylord, Abigail

AU - Fry, Rebecca C.

AU - Oken, Emily

AU - O’Connor, George

AU - Ruden, Douglas M.

AU - Trasande, Leonardo

AU - Herbstman, Julie B.

AU - Camargo, Carlos A.

AU - Bush, Nicole R.

AU - Dunlop, Anne L.

AU - Dabelea, Dana M.

AU - Karagas, Margaret R.

AU - Breton, Carrie V.

AU - Ober, Carole

AU - Everson, Todd M.

AU - Page, Grier P.

AU - Ladd-Acosta, Christine

AU - Smith, P. B.

AU - Newby, L. K.

AU - Jacobson, L. P.

AU - Catellier, D. J.

AU - Gershon, R.

AU - Cella, D.

AU - Laham, F. R.

AU - Mansbach, J. M.

AU - Wu, S.

AU - Spergel, J. M.

AU - Celedón, J. C.

AU - Puls, H. T.

AU - Teach, S. J.

AU - Porter, S. C.

AU - Waynik, I. Y.

AU - Iyer, S. S.

AU - Samuels-Kalow, M. E.

AU - D.Thompson, A.

AU - Stevenson, M. D.

AU - Bauer, C. S.

AU - Inhofe, N. R.

AU - Boos, M.

PY - 2023/12

Y1 - 2023/12

N2 - Background: Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination. Results: Our study used data from seven tissue types on three DNA methylation profiling microarrays and found that the Knight and Bohlin clocks performed similarly for blood cells, while the Lee clock was superior for placental samples. The pediatric-buccal-epigenetic clock performed the best for pediatric buccal samples, while the Horvath clock is recommended for children's blood cell samples. The NeoAge clock stands out for its unique ability to predict post-menstrual age with high correlation with the observed age in infant buccal cell samples. Conclusions: Our findings provide valuable guidance for future research and development of epigenetic clocks in pediatric samples, enabling more accurate assessments of biological age.

AB - Background: Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination. Results: Our study used data from seven tissue types on three DNA methylation profiling microarrays and found that the Knight and Bohlin clocks performed similarly for blood cells, while the Lee clock was superior for placental samples. The pediatric-buccal-epigenetic clock performed the best for pediatric buccal samples, while the Horvath clock is recommended for children's blood cell samples. The NeoAge clock stands out for its unique ability to predict post-menstrual age with high correlation with the observed age in infant buccal cell samples. Conclusions: Our findings provide valuable guidance for future research and development of epigenetic clocks in pediatric samples, enabling more accurate assessments of biological age.

KW - DNA methylation

KW - Early childhood chronological age

KW - Epigenetic clock

KW - Gestational age

UR - http://www.scopus.com/inward/record.url?scp=85169709590&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85169709590&partnerID=8YFLogxK

U2 - 10.1186/s13148-023-01552-3

DO - 10.1186/s13148-023-01552-3

M3 - Article

C2 - 37660147

AN - SCOPUS:85169709590

SN - 1868-7075

VL - 15

JO - Clinical Epigenetics

JF - Clinical Epigenetics

IS - 1

M1 - 142

ER -

Evaluation of pediatric epigenetic clocks across multiple tissues

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this