Evaluation of the α(2A)adrenergic receptor gene in a heritable form of temporal lobe epilepsy

M. H. Wilson*, R. S. Puranam, Ruth Ottman, C. Gilliam, L. E. Limbird, A. L. George, J. O. McNamara

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

An autosomal dominant form of human temporal lobe epilepsy (TLE) has been mapped to a region of chromosome 10q that contains the intronless α(2A)-adrenergic receptor (α(2A) AR) gene. Because mutation of the α(2A)AR gene in the mouse fosters epileptogenesis, we developed methods for analysis of the α(2A)AR coding region applicable to any pathophysiologic state in which the α(2A)AR could be implicated in the disease mechanism. This study rules out mutations in the 2a(2A)AR coding region as causal for this form of autosomal dominant TLE.

Original languageEnglish (US)
Pages (from-to)1730-1731
Number of pages2
JournalNeurology
Volume51
Issue number6
DOIs
StatePublished - Dec 1998

ASJC Scopus subject areas

  • Clinical Neurology

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    Wilson, M. H., Puranam, R. S., Ottman, R., Gilliam, C., Limbird, L. E., George, A. L., & McNamara, J. O. (1998). Evaluation of the α(2A)adrenergic receptor gene in a heritable form of temporal lobe epilepsy. Neurology, 51(6), 1730-1731. https://doi.org/10.1212/WNL.51.6.1730