TY - JOUR
T1 - Evaluation of the Aberrant Behavior Checklist for Developmental and Epileptic Encephalopathies
AU - Kaat, Aaron J.
AU - Zelko, Frank
AU - Wilkening, Greta
AU - Berg, Anne T.
N1 - Funding Information:
Funding: This work was supported by the Stanley Manne Children’s Research Institute and Ann & Robert H. Lurie Children’s Hospital of Chicago under the Precision Medicine Strategic Research Initiative and by a grant from the Pediatric Epilepsy Research Consortium , Dallas, TX. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding sources.
Funding Information:
Funding: This work was supported by the Stanley Manne Children's Research Institute and Ann & Robert H. Lurie Children's Hospital of Chicago under the Precision Medicine Strategic Research Initiative and by a grant from the Pediatric Epilepsy Research Consortium, Dallas, TX. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding sources.
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/6
Y1 - 2021/6
N2 - Objectives: To determine the suitability of the Aberrant Behavior Checklist (ABC)—a common measure used in clinical trials for treatment of challenging behaviors of autism—as an outcome measure for pharmacological and behavioral interventions for young people with Developmental and Epileptic Encephalopathies (DEEs). Methods: We assessed score profiles on the ABC in a sample of 122 young people with DEEs, including Dravet and Lennox–Gastaut syndromes, and KCNQ2- SCN2A-, and KCNB1-associated disorders. Then we examined its internal structure using item cluster analysis. We used both unrestricted item cluster analysis to determine the number of item clusters that maximize reliability and restricted analyses in which we pre-specified models with 5-, 6-, and 7-clusters, to examine consistency with previous factor analytic studies. We also conducted validity analysis on the various scoring methods with age, sex, and autism spectrum screening measure scores. Results: Unrestricted item cluster analysis suggested that three clusters maximized reliability of ABC scores. These broadly represented other-directed behaviors (i.e., “externalizing”), self-directed behaviors (i.e., “internalizing”), and inappropriate speech. Restricted models separated item clusters for stereotypy from other self-directed problem behaviors, and self-injurious behaviors from the other externalizing behaviors. Validity analysis also supported these structures. Overall, all scores were low, and less than 20% of DEE participants had symptoms severe enough to qualify for most randomized trials of behavioral therapies. Significance: These results are broadly consistent with the extant ABC scoring algorithms. They suggest a high internal consistency reliability, which may support the use of the ABC in future clinical trials in patients with DEEs who exhibit the behaviors assessed by the ABC. Alternatively, concerns about overall low scores raise cautions about using the ABC as a measure of behavior in unselected populations with DEE.
AB - Objectives: To determine the suitability of the Aberrant Behavior Checklist (ABC)—a common measure used in clinical trials for treatment of challenging behaviors of autism—as an outcome measure for pharmacological and behavioral interventions for young people with Developmental and Epileptic Encephalopathies (DEEs). Methods: We assessed score profiles on the ABC in a sample of 122 young people with DEEs, including Dravet and Lennox–Gastaut syndromes, and KCNQ2- SCN2A-, and KCNB1-associated disorders. Then we examined its internal structure using item cluster analysis. We used both unrestricted item cluster analysis to determine the number of item clusters that maximize reliability and restricted analyses in which we pre-specified models with 5-, 6-, and 7-clusters, to examine consistency with previous factor analytic studies. We also conducted validity analysis on the various scoring methods with age, sex, and autism spectrum screening measure scores. Results: Unrestricted item cluster analysis suggested that three clusters maximized reliability of ABC scores. These broadly represented other-directed behaviors (i.e., “externalizing”), self-directed behaviors (i.e., “internalizing”), and inappropriate speech. Restricted models separated item clusters for stereotypy from other self-directed problem behaviors, and self-injurious behaviors from the other externalizing behaviors. Validity analysis also supported these structures. Overall, all scores were low, and less than 20% of DEE participants had symptoms severe enough to qualify for most randomized trials of behavioral therapies. Significance: These results are broadly consistent with the extant ABC scoring algorithms. They suggest a high internal consistency reliability, which may support the use of the ABC in future clinical trials in patients with DEEs who exhibit the behaviors assessed by the ABC. Alternatively, concerns about overall low scores raise cautions about using the ABC as a measure of behavior in unselected populations with DEE.
KW - Aberrant Behavior Checklist
KW - Children
KW - Developmental and Epileptic Encephalopathies
KW - Intellectual disability
KW - Item cluster analysis
KW - Trial readiness
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U2 - 10.1016/j.yebeh.2021.107958
DO - 10.1016/j.yebeh.2021.107958
M3 - Article
C2 - 33892287
AN - SCOPUS:85104381092
SN - 1525-5050
VL - 119
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
M1 - 107958
ER -