Evaluation of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 Palliative Care and the Functional Assessment of Chronic Illness Therapy-Palliative in assessing the quality of life in patients with advanced cancer

Paula Tur; Eva Oldenburger; Andrew Bottomley; David Cella; Shing Fung Lee; Adrian W. Chan; Gustavo Nader Marta; Timothy Jacobs; Edward Chow; Henry C.Y. Wong; Agata Rembielak

doi:10.1097/SPC.0000000000000750

Evaluation of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 Palliative Care and the Functional Assessment of Chronic Illness Therapy-Palliative in assessing the quality of life in patients with advanced cancer

Paula Tur, Eva Oldenburger, Andrew Bottomley, David Cella, Shing Fung Lee, Adrian W. Chan, Gustavo Nader Marta, Timothy Jacobs, Edward Chow, Henry C.Y. Wong^*, Agata Rembielak

^*Corresponding author for this work

Medical Social Sciences

Research output: Contribution to journal › Review article › peer-review

Abstract

Purpose of review Two widely validated health-related quality of life (HR-QoL) tools, specifically designed for patients with advanced cancer, are the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 15 Palliative Care (EORTC QLQ-C15-PAL) and the Functional Assessment of Chronic Illness Therapy-Palliative (FACIT-Pal-14). This systematic review aims to evaluate the use of EORTC QLQ-C15-PAL and FACIT-Pal-14 in prospective studies in patients with advanced cancer, focusing on study types, clinical settings, additional HR-QoL tools used, and completion rates. Recent findings Sixty studies were included in the analysis. Both EORTC QLQ-C15-PAL and FACIT-Pal-14 are used in a variety of studies. Given that EORTC QLQ-C15-PAL was developed 9 years before FACIT-Pal-14 PAL, most studies utilized the EORTC tool. Both tools were shown to be successfully used in a variety of clinical settings, including in various advanced tumour types or different study designs, depending on the investigator and study needs. Summary This review demonstrates the wide range of utilization of EORTC QLQ-C15-PAL and FACIT-Pal-14 in prospective studies to assess the HR-QoL issues in patients with advanced cancers.

Original language	English (US)
Article number	10.1097/SPC.0000000000000750
Journal	Current opinion in supportive and palliative care
DOIs	https://doi.org/10.1097/SPC.0000000000000750
State	Accepted/In press - 2025

Keywords

advanced cancer
EORTC QLQ-C15-PAL
FACIT-Pal-14
quality of life
questionnaires

ASJC Scopus subject areas

Oncology
Oncology(nursing)
Critical Care and Intensive Care Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/SPC.0000000000000750

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Tur, P., Oldenburger, E., Bottomley, A., Cella, D., Lee, S. F., Chan, A. W., Marta, G. N., Jacobs, T., Chow, E., Wong, H. C. Y., & Rembielak, A. (Accepted/In press). Evaluation of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 Palliative Care and the Functional Assessment of Chronic Illness Therapy-Palliative in assessing the quality of life in patients with advanced cancer. Current opinion in supportive and palliative care, Article 10.1097/SPC.0000000000000750. https://doi.org/10.1097/SPC.0000000000000750

Tur, Paula ; Oldenburger, Eva ; Bottomley, Andrew et al. / Evaluation of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 Palliative Care and the Functional Assessment of Chronic Illness Therapy-Palliative in assessing the quality of life in patients with advanced cancer. In: Current opinion in supportive and palliative care. 2025.

@article{23b40ce051864fc4afff1a7bee33410a,

title = "Evaluation of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 Palliative Care and the Functional Assessment of Chronic Illness Therapy-Palliative in assessing the quality of life in patients with advanced cancer",

abstract = "Purpose of review Two widely validated health-related quality of life (HR-QoL) tools, specifically designed for patients with advanced cancer, are the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 15 Palliative Care (EORTC QLQ-C15-PAL) and the Functional Assessment of Chronic Illness Therapy-Palliative (FACIT-Pal-14). This systematic review aims to evaluate the use of EORTC QLQ-C15-PAL and FACIT-Pal-14 in prospective studies in patients with advanced cancer, focusing on study types, clinical settings, additional HR-QoL tools used, and completion rates. Recent findings Sixty studies were included in the analysis. Both EORTC QLQ-C15-PAL and FACIT-Pal-14 are used in a variety of studies. Given that EORTC QLQ-C15-PAL was developed 9 years before FACIT-Pal-14 PAL, most studies utilized the EORTC tool. Both tools were shown to be successfully used in a variety of clinical settings, including in various advanced tumour types or different study designs, depending on the investigator and study needs. Summary This review demonstrates the wide range of utilization of EORTC QLQ-C15-PAL and FACIT-Pal-14 in prospective studies to assess the HR-QoL issues in patients with advanced cancers.",

keywords = "advanced cancer, EORTC QLQ-C15-PAL, FACIT-Pal-14, quality of life, questionnaires",

author = "Paula Tur and Eva Oldenburger and Andrew Bottomley and David Cella and Lee, {Shing Fung} and Chan, {Adrian W.} and Marta, {Gustavo Nader} and Timothy Jacobs and Edward Chow and Wong, {Henry C.Y.} and Agata Rembielak",

note = "Publisher Copyright: {\textcopyright} 2025 Wolters Kluwer Health, Inc.",

year = "2025",

doi = "10.1097/SPC.0000000000000750",

language = "English (US)",

journal = "Current opinion in supportive and palliative care",

issn = "1751-4258",

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Tur, P, Oldenburger, E, Bottomley, A, Cella, D, Lee, SF, Chan, AW, Marta, GN, Jacobs, T, Chow, E, Wong, HCY & Rembielak, A 2025, 'Evaluation of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 Palliative Care and the Functional Assessment of Chronic Illness Therapy-Palliative in assessing the quality of life in patients with advanced cancer', Current opinion in supportive and palliative care. https://doi.org/10.1097/SPC.0000000000000750

Evaluation of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 Palliative Care and the Functional Assessment of Chronic Illness Therapy-Palliative in assessing the quality of life in patients with advanced cancer. / Tur, Paula; Oldenburger, Eva; Bottomley, Andrew et al.
In: Current opinion in supportive and palliative care, 2025.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Evaluation of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 Palliative Care and the Functional Assessment of Chronic Illness Therapy-Palliative in assessing the quality of life in patients with advanced cancer

AU - Tur, Paula

AU - Oldenburger, Eva

AU - Bottomley, Andrew

AU - Cella, David

AU - Lee, Shing Fung

AU - Chan, Adrian W.

AU - Marta, Gustavo Nader

AU - Jacobs, Timothy

AU - Chow, Edward

AU - Wong, Henry C.Y.

AU - Rembielak, Agata

PY - 2025

Y1 - 2025

N2 - Purpose of review Two widely validated health-related quality of life (HR-QoL) tools, specifically designed for patients with advanced cancer, are the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 15 Palliative Care (EORTC QLQ-C15-PAL) and the Functional Assessment of Chronic Illness Therapy-Palliative (FACIT-Pal-14). This systematic review aims to evaluate the use of EORTC QLQ-C15-PAL and FACIT-Pal-14 in prospective studies in patients with advanced cancer, focusing on study types, clinical settings, additional HR-QoL tools used, and completion rates. Recent findings Sixty studies were included in the analysis. Both EORTC QLQ-C15-PAL and FACIT-Pal-14 are used in a variety of studies. Given that EORTC QLQ-C15-PAL was developed 9 years before FACIT-Pal-14 PAL, most studies utilized the EORTC tool. Both tools were shown to be successfully used in a variety of clinical settings, including in various advanced tumour types or different study designs, depending on the investigator and study needs. Summary This review demonstrates the wide range of utilization of EORTC QLQ-C15-PAL and FACIT-Pal-14 in prospective studies to assess the HR-QoL issues in patients with advanced cancers.

AB - Purpose of review Two widely validated health-related quality of life (HR-QoL) tools, specifically designed for patients with advanced cancer, are the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 15 Palliative Care (EORTC QLQ-C15-PAL) and the Functional Assessment of Chronic Illness Therapy-Palliative (FACIT-Pal-14). This systematic review aims to evaluate the use of EORTC QLQ-C15-PAL and FACIT-Pal-14 in prospective studies in patients with advanced cancer, focusing on study types, clinical settings, additional HR-QoL tools used, and completion rates. Recent findings Sixty studies were included in the analysis. Both EORTC QLQ-C15-PAL and FACIT-Pal-14 are used in a variety of studies. Given that EORTC QLQ-C15-PAL was developed 9 years before FACIT-Pal-14 PAL, most studies utilized the EORTC tool. Both tools were shown to be successfully used in a variety of clinical settings, including in various advanced tumour types or different study designs, depending on the investigator and study needs. Summary This review demonstrates the wide range of utilization of EORTC QLQ-C15-PAL and FACIT-Pal-14 in prospective studies to assess the HR-QoL issues in patients with advanced cancers.

KW - advanced cancer

KW - EORTC QLQ-C15-PAL

KW - FACIT-Pal-14

KW - quality of life

KW - questionnaires

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JO - Current opinion in supportive and palliative care

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ER -

Tur P, Oldenburger E, Bottomley A, Cella D, Lee SF, Chan AW et al. Evaluation of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 Palliative Care and the Functional Assessment of Chronic Illness Therapy-Palliative in assessing the quality of life in patients with advanced cancer. Current opinion in supportive and palliative care. 2025;10.1097/SPC.0000000000000750. doi: 10.1097/SPC.0000000000000750

Evaluation of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 Palliative Care and the Functional Assessment of Chronic Illness Therapy-Palliative in assessing the quality of life in patients with advanced cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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