Evaluation of ventricular synchrony using novel Doppler echocardiographic indices in patients with heart failure receiving cardiac resynchronization therapy

Jing Ping Sun, Edward Chinchoy, Erwan Donal, Zoran B. Popović, George Perlic, Craig R. Asher, Neil L. Greenberg, Richard A. Grimm, Bruce L. Wilkoff, James D. Thomas*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Cardiac resynchronization therapy improves hemodynamics in selected patients with heart failure. Mechanic asynchrony parameters that may guide patient selection or therapy optimization are still being investigated. A biventricular (BiV) pacemaker was implanted in 34 patients with dilated ischemic, idiopathic, or valvular cardiomyopathy, and a QRS duration of ≥130 milliseconds. Two-dimensional standard and Doppler tissue echocardiography was performed during right ventricular (RV), left ventricular (LV), BiV, and no pacing in a random and blinded manner. LV and BiV pacing increased stroke volume (P < .02 for both) and ejection fraction (P < .001 for both). Regional contractility assessed by displacement, strain rate, and peak systolic strain was improved in some segments (P < .05) during LV and BiV pacing. A homogenization of segmental contractions was observed during LV and BiV pacing as evaluated by net systolic displacement and segmental myocardial performance index. LV and BiV pacing provides benefits that can be quantified by echocardiography.

Original languageEnglish (US)
Pages (from-to)845-850
Number of pages6
JournalJournal of the American Society of Echocardiography
Volume17
Issue number8
DOIs
StatePublished - Aug 2004

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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