Evidence for and against regional differences in neural stem and progenitor cells of the CNS

Oren J. Becher; Eric C. Holland

doi:10.1101/gad.1988010

Evidence for and against regional differences in neural stem and progenitor cells of the CNS

Oren J. Becher, Eric C. Holland

Pediatrics

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Neural stem and progenitor cells (NSCs) give rise to the cellular diversity of the CNS. There is evidence both for and against differences in these cells based on the region of the brain in which they reside. Primary brain tumors mimic many aspects of NSC behavior. Recent data suggest that some of the variability in glioma biology may be, in part, a reflection of regional differences in the NSCs from which they arise. In this issue of Genes & Development, Lee and colleagues (pp. 2317-2329) examine how NF1 regulates NSC proliferation and glial differentiation in the brainstem and cortex of the postnatal mouse brain.

Original language	English (US)
Pages (from-to)	2233-2238
Number of pages	6
Journal	Genes and Development
Volume	24
Issue number	20
DOIs	https://doi.org/10.1101/gad.1988010
State	Published - Oct 15 2010

Keywords

Akt
Gliogenesis
Neural stem cell
Neurofibromin
Regional heterogeneity
mTOR

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1101/gad.1988010

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abstract = "Neural stem and progenitor cells (NSCs) give rise to the cellular diversity of the CNS. There is evidence both for and against differences in these cells based on the region of the brain in which they reside. Primary brain tumors mimic many aspects of NSC behavior. Recent data suggest that some of the variability in glioma biology may be, in part, a reflection of regional differences in the NSCs from which they arise. In this issue of Genes & Development, Lee and colleagues (pp. 2317-2329) examine how NF1 regulates NSC proliferation and glial differentiation in the brainstem and cortex of the postnatal mouse brain.",

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AB - Neural stem and progenitor cells (NSCs) give rise to the cellular diversity of the CNS. There is evidence both for and against differences in these cells based on the region of the brain in which they reside. Primary brain tumors mimic many aspects of NSC behavior. Recent data suggest that some of the variability in glioma biology may be, in part, a reflection of regional differences in the NSCs from which they arise. In this issue of Genes & Development, Lee and colleagues (pp. 2317-2329) examine how NF1 regulates NSC proliferation and glial differentiation in the brainstem and cortex of the postnatal mouse brain.

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KW - Neurofibromin

KW - Regional heterogeneity

KW - mTOR

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Evidence for and against regional differences in neural stem and progenitor cells of the CNS

Abstract

Keywords

ASJC Scopus subject areas

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