Evidence for and against regional differences in neural stem and progenitor cells of the CNS

Oren J. Becher, Eric C. Holland

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Neural stem and progenitor cells (NSCs) give rise to the cellular diversity of the CNS. There is evidence both for and against differences in these cells based on the region of the brain in which they reside. Primary brain tumors mimic many aspects of NSC behavior. Recent data suggest that some of the variability in glioma biology may be, in part, a reflection of regional differences in the NSCs from which they arise. In this issue of Genes & Development, Lee and colleagues (pp. 2317-2329) examine how NF1 regulates NSC proliferation and glial differentiation in the brainstem and cortex of the postnatal mouse brain.

Original languageEnglish (US)
Pages (from-to)2233-2238
Number of pages6
JournalGenes and Development
Volume24
Issue number20
DOIs
StatePublished - Oct 15 2010

Keywords

  • Akt
  • Gliogenesis
  • Neural stem cell
  • Neurofibromin
  • Regional heterogeneity
  • mTOR

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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