Evidence for distinct human auditory cortex regions for sound location versus identity processing

Jyrki Ahveninen; Samantha Huang; Aapo Nummenmaa; John W. Belliveau; An Yi Hung; Iiro P. Jääskeläinen; Josef P. Rauschecker; Stephanie Rossi; Hannu Tiitinen; Tommi Raij

doi:10.1038/ncomms3585

Evidence for distinct human auditory cortex regions for sound location versus identity processing

Jyrki Ahveninen^*, Samantha Huang, Aapo Nummenmaa, John W. Belliveau, An Yi Hung, Iiro P. Jääskeläinen, Josef P. Rauschecker, Stephanie Rossi, Hannu Tiitinen, Tommi Raij

^*Corresponding author for this work

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Neurophysiological animal models suggest that anterior auditory cortex (AC) areas process sound identity information, whereas posterior ACs specialize in sound location processing. In humans, inconsistent neuroimaging results and insufficient causal evidence have challenged the existence of such parallel AC organization. Here we transiently inhibit bilateral anterior or posterior AC areas using MRI-guided paired-pulse transcranial magnetic stimulation (TMS) while subjects listen to Reference/Probe sound pairs and perform either sound location or identity discrimination tasks. The targeting of TMS pulses, delivered 55-145 ms after Probes, is confirmed with individual-level cortical electric-field estimates. Our data show that TMS to posterior AC regions delays reaction times (RT) significantly more during sound location than identity discrimination, whereas TMS to anterior AC regions delays RTs significantly more during sound identity than location discrimination. This double dissociation provides direct causal support for parallel processing of sound identity features in anterior AC and sound location in posterior AC.

Original language	English (US)
Article number	2585
Journal	Nature communications
Volume	4
DOIs	https://doi.org/10.1038/ncomms3585
State	Published - 2013

Funding

We thank Mary O’Hara, Nancy Shearer, Chinmayi Tengshe and Lawrence White, as well as Drs Wei-Tang Chang, Sharon Furtak, Matti Hämäläinen and Norbert Kopcˇo. This research was supported by the National Institutes of Health (NIH) Grants R21DC010060, R01MH083744, R01HD040712, R01NS037462, R01NS048279 and K99EB015445. The research environment was supported by the NIH/National Institute of Biomedical Imaging and Bioengineering (NIBIB) Grant P41EB015896 (Center for Functional Neuroimaging Techniques, CFNT), NIH Shared Instrumentation Grant S10-RR024694, and the Harvard Clinical and Translational Science Center (Harvard Catalyst; NCRR-NIH UL1 RR025758; NCRR-NIH UL1 TR000170). I.P.J. was supported by the Academy Of Finland Grant 130412, and J.P.R was supported by the NIH Grant R56NS052494 and by the National Science Foundation Grant NSF PIRE-OISE-0730255. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.

ASJC Scopus subject areas

General Physics and Astronomy
General Chemistry
General Biochemistry, Genetics and Molecular Biology

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10.1038/ncomms3585

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@article{97a0cb2f53c843b9a730d3510503844d,

title = "Evidence for distinct human auditory cortex regions for sound location versus identity processing",

abstract = "Neurophysiological animal models suggest that anterior auditory cortex (AC) areas process sound identity information, whereas posterior ACs specialize in sound location processing. In humans, inconsistent neuroimaging results and insufficient causal evidence have challenged the existence of such parallel AC organization. Here we transiently inhibit bilateral anterior or posterior AC areas using MRI-guided paired-pulse transcranial magnetic stimulation (TMS) while subjects listen to Reference/Probe sound pairs and perform either sound location or identity discrimination tasks. The targeting of TMS pulses, delivered 55-145 ms after Probes, is confirmed with individual-level cortical electric-field estimates. Our data show that TMS to posterior AC regions delays reaction times (RT) significantly more during sound location than identity discrimination, whereas TMS to anterior AC regions delays RTs significantly more during sound identity than location discrimination. This double dissociation provides direct causal support for parallel processing of sound identity features in anterior AC and sound location in posterior AC.",

author = "Jyrki Ahveninen and Samantha Huang and Aapo Nummenmaa and Belliveau, {John W.} and Hung, {An Yi} and J{\"a}{\"a}skel{\"a}inen, {Iiro P.} and Rauschecker, {Josef P.} and Stephanie Rossi and Hannu Tiitinen and Tommi Raij",

note = "Funding Information: We thank Mary O{\textquoteright}Hara, Nancy Shearer, Chinmayi Tengshe and Lawrence White, as well as Drs Wei-Tang Chang, Sharon Furtak, Matti H{\"a}m{\"a}l{\"a}inen and Norbert Kopcˇo. This research was supported by the National Institutes of Health (NIH) Grants R21DC010060, R01MH083744, R01HD040712, R01NS037462, R01NS048279 and K99EB015445. The research environment was supported by the NIH/National Institute of Biomedical Imaging and Bioengineering (NIBIB) Grant P41EB015896 (Center for Functional Neuroimaging Techniques, CFNT), NIH Shared Instrumentation Grant S10-RR024694, and the Harvard Clinical and Translational Science Center (Harvard Catalyst; NCRR-NIH UL1 RR025758; NCRR-NIH UL1 TR000170). I.P.J. was supported by the Academy Of Finland Grant 130412, and J.P.R was supported by the NIH Grant R56NS052494 and by the National Science Foundation Grant NSF PIRE-OISE-0730255. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.",

year = "2013",

doi = "10.1038/ncomms3585",

language = "English (US)",

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journal = "Nature communications",

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AU - Ahveninen, Jyrki

AU - Huang, Samantha

AU - Nummenmaa, Aapo

AU - Belliveau, John W.

AU - Hung, An Yi

AU - Jääskeläinen, Iiro P.

AU - Rauschecker, Josef P.

AU - Rossi, Stephanie

AU - Tiitinen, Hannu

AU - Raij, Tommi

N1 - Funding Information: We thank Mary O’Hara, Nancy Shearer, Chinmayi Tengshe and Lawrence White, as well as Drs Wei-Tang Chang, Sharon Furtak, Matti Hämäläinen and Norbert Kopcˇo. This research was supported by the National Institutes of Health (NIH) Grants R21DC010060, R01MH083744, R01HD040712, R01NS037462, R01NS048279 and K99EB015445. The research environment was supported by the NIH/National Institute of Biomedical Imaging and Bioengineering (NIBIB) Grant P41EB015896 (Center for Functional Neuroimaging Techniques, CFNT), NIH Shared Instrumentation Grant S10-RR024694, and the Harvard Clinical and Translational Science Center (Harvard Catalyst; NCRR-NIH UL1 RR025758; NCRR-NIH UL1 TR000170). I.P.J. was supported by the Academy Of Finland Grant 130412, and J.P.R was supported by the NIH Grant R56NS052494 and by the National Science Foundation Grant NSF PIRE-OISE-0730255. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.

PY - 2013

Y1 - 2013

N2 - Neurophysiological animal models suggest that anterior auditory cortex (AC) areas process sound identity information, whereas posterior ACs specialize in sound location processing. In humans, inconsistent neuroimaging results and insufficient causal evidence have challenged the existence of such parallel AC organization. Here we transiently inhibit bilateral anterior or posterior AC areas using MRI-guided paired-pulse transcranial magnetic stimulation (TMS) while subjects listen to Reference/Probe sound pairs and perform either sound location or identity discrimination tasks. The targeting of TMS pulses, delivered 55-145 ms after Probes, is confirmed with individual-level cortical electric-field estimates. Our data show that TMS to posterior AC regions delays reaction times (RT) significantly more during sound location than identity discrimination, whereas TMS to anterior AC regions delays RTs significantly more during sound identity than location discrimination. This double dissociation provides direct causal support for parallel processing of sound identity features in anterior AC and sound location in posterior AC.

AB - Neurophysiological animal models suggest that anterior auditory cortex (AC) areas process sound identity information, whereas posterior ACs specialize in sound location processing. In humans, inconsistent neuroimaging results and insufficient causal evidence have challenged the existence of such parallel AC organization. Here we transiently inhibit bilateral anterior or posterior AC areas using MRI-guided paired-pulse transcranial magnetic stimulation (TMS) while subjects listen to Reference/Probe sound pairs and perform either sound location or identity discrimination tasks. The targeting of TMS pulses, delivered 55-145 ms after Probes, is confirmed with individual-level cortical electric-field estimates. Our data show that TMS to posterior AC regions delays reaction times (RT) significantly more during sound location than identity discrimination, whereas TMS to anterior AC regions delays RTs significantly more during sound identity than location discrimination. This double dissociation provides direct causal support for parallel processing of sound identity features in anterior AC and sound location in posterior AC.

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ER -

Evidence for distinct human auditory cortex regions for sound location versus identity processing

Abstract

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ASJC Scopus subject areas

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